Streptococcus pneumoniae

Phenotypic and Genotypic Characteristics of Pneumococci Isolated from Patients with Pneumococcal Meningitis

Antimicrobial susceptibility, serotype distribution, and multilocus sequence types of Streptococcus pneumoniae isolated from the patients with meningitis were determined. We tested a total of 84 isolates which have been obtained in Moscow during …

Antimicrobial Resistance of Streptococcus pneumoniae in Russia over the 1999–2009: Results of Multicenter Prospective Study PEHASus

Objective. To assess antimicrobial resistance and its trends among Streptococcus pneumoniae in different regions of Russia over the 1999-2009. Materials and Methods. A total of 2419 S. pneumoniae strains from different cities of Central, NorthWestern, Southern, Volga, Ural, Siberia, Far-Eastern regions of Russia were included into the study over the period from 1999 to 2009. Susceptibility to 23 antimicrobials was determined using microdilution method according to Clinical and Laboratory Standards Institute (CLSI) guidelines.

Acute Bacterial Rhinosinusitis in Young Soldiers: Etiology, Susceptibility and Antimicrobial Therapy

The objectives of this study were to investigate etiology of acute bacterial rhinosinusitis (ABR) in young soldiers, to determine susceptibility to different antimicrobial agents and to assess clinical efficacy of antimicrobial therapy in ABR. …

Antimicrobial Resistance of Streptococcus pneumoniae in Russia in 1999–2005: Results of Multicentre Prospective Studies PEHASus-I and PEHASus-II

Objective. Objective: To assess the level, structure and phenotypes of antimicrobial resistance of Streptococcus pneumoniae in different regions of Russia and to evaluate their dynamics in period from 1999 to 2005. Materials and Methods. A total of 1704 S. pneumoniae from 23 cities of Central, North-Western, Southern, Privolgsk, Ural, Siberian and Far-Eastern regions of Russia were included into the study from 1999 to 2005. Susceptibility to 17 antimicrobials was determined by microdilution in accordance with Clinical and Laboratory Standards Institute/National Committee for Clinical Laboratory Standards (CLSI/NCCLS).

New Approaches to the Optimization of Antimicrobial Therapy of Respiratory Tract Infections Using Pharmacokinetic and Pharmacodynamic Parameters

To understand the relationship between drug dose and efficacy, pharmacokinetic (PK) and pharmacodynamic (PD) characteristics need to be integrated. There are two patterns of antimicrobial activity: time-dependent killing and concentration-dependent …

Practice Guidelines on Antimicrobial Therapy of Sinusitis

This paper presents data on epidemiology and etiology of sinusitis in Russia as well as antimicrobial susceptibility patterns of most likely pathogens, causing different forms of the disease. Choice of antimicrobials for treatment of different types …

Antimicrobial Resistance of Streptococcus Pneumoniae in Different Regions of Russia: Results of Prospective Multicentre Study (phase А of project PeHAS-I)

Objective. To determine the structure of antimicrobial resistance of clinical isolates of pneumococci in different regions of Russia. Materials and Methods. A total of 210 Streptococcus pneumoniae strains isolated in 15 centres of Central (Moscow – 5 centers, Kazan, Nizniy Novgorod, Ryzan), North-Western (Smolensk, Saint-Petersburg), Southern (Krasnodar) regions, Urals (Ekaterinburg) and Siberia (Novosibirsk, Tomsk) were included in this study. Susceptibility to 19 antimicrobials – penicillin G, amoxicillin, amoxicillin/clavulanate, cefotaxime, cefepime, erythromycin, azithromycin, clarithromycin, midecamycin, midecamycin acetate, spiramycin, clindamycin, tetracycline, ciprofloxacin, levolfloxacin, chloramphenicol, co-trimoxazole, rifampicin and vancomycin – was determined by broth microdilution in accordance with NCCLS recommendations.