Streptococcus pneumoniae

Antimicrobial resistance of clinical Streptococcus pneumoniae isolates in Russia: the results of multicenter epidemiological study «PEHASus 2014–2017»

Objective. To evaluate antimicrobial resistance patterns of clinical Streptococcus pneumoniae isolates from different regions of Russia during 2014–2017. Materials and Methods. We included in the study 519 clinical S. pneumoniae isolates from 18 Russian cities. Susceptibility testing was performed by reference broth microdilution method (ISO 20776-1:2006). Susceptibility testing results were interpreted according to EUCAST v.9.0 breakpoints. Results. Using EUCAST non-meningeal interpretation criteria, 65.1% of isolates tested were susceptible (S) to penicillin; in addition 28.

Antimicrobial susceptibility of Streptococcus pneumoniae in Kazakhstan

Objective. To study antimicrobial susceptibility of Streptococcus pneumoniae clinical isolates obtained from the patients with community-acquired pneumonia in the Central Kazakhstan. Materials and Methods. A total of 186 clinical strains of S. pneumoniae were obtained from the patients with respiratory tract infections in the Central Kazakhstan over the period of 2012–2017. Antimicrobial susceptibility was determined by disk-diffusion method. The isolation and identification of pathogens was performed by routine methods. Antimicrobial (oxacillin, vancomycin, clindamycin, azithromycin, chloramphenicol, tetracycline, rifampin, levofloxacin, linezolid, trimethoprim/sulfamethoxazole) susceptibility testing was performed and interpreted according to CLSI criteria (M100-24).

Antimicrobial susceptibility and association with serotypes of Streptococcus pneumoniae isolates in children with acute otitis media and acute sinusitis in Belarus

Objective. To study antibiotic resistance and its association with serotypes of Streptococcus pneumoniae isolated from hospitalized children with community-acquired ENT infections in Belarus during 2013-2016 and to analyze a potential for the use of different antibiotic classes in the treatment of those infections. Materials and Methods. A total of 115 strains isolated from children with acute otitis media and 18 strains isolated from children with acute rhinosinusitis were tested. Antimicrobial susceptibility testing was performed by a broth microdilution method.

Antimicrobial resistance and clonal evolution of Streptococcus pneumoniae serotype 19A in Russia during 2002-2013

After the introduction of the conjugated 7-valent pneumococcal vaccine (PCV7) the incidence of infections, caused by non-vaccine serotypes of S. pneumoniae, especially by 19А serotype, significantly increased. But in few countries similar phenomenon …

Clinico-Economic Effectiveness of Ceftaroline Fosamil for the Treatment of Hospitalised Patients with Pneumococcal Community-Acquired Pneumonia from a Societal Perspective

Objective. Due to high activity against Streptococcus pneumoniae ceftaroline fosamil (CF) presents a good option for the treatment of adults with pneumococcal communityacquired pneumonia (PCAP) requiring parenteral antibacterial therapy. We aimed to assess cost-effectiveness of CF for the treatment of PCAP in a multi-field hospital in Russia from a societal perspective. Materials and Methods. Decision tree model based on the results of two 3rd phase clinical trials (FOCUS 1, FOCUS 2) was created to represent a standard approach to the management of hospitalised patients with PCAP and estimated outcomes including possible recurrence of infection, direct and delayed attributive mortality in case of initial therapy with CF 600 mg BID vs.

Antimicrobial Susceptibility of Pediatric Streptococcus pneumoniae Isolates in Krasnoyarsk

Streptococcus pneumoniae strains isolated from children of Krasnoyarsk (Siberia, Russian Federation) were examined. Authors determined Streptococcus pneumoniae serotypes and antimicrobial resistance. 16.7% of strains were multiple resistant with high …

PCR-based Identification and Serotyping of Russian Streptococcus pneumoniae Strains

The techniques for PCR-based identification and serotyping of Streptococcus pneumoniae were optimized for using in Russian epidemiologic situation. One hundred and thirteen strains isolated from children under 5 years of age in 15 Russian cities were …

Phenotypic and Genotypic Characteristics of Pneumococci Isolated from Patients with Pneumococcal Meningitis

Antimicrobial susceptibility, serotype distribution, and multilocus sequence types of Streptococcus pneumoniae isolated from the patients with meningitis were determined. We tested a total of 84 isolates which have been obtained in Moscow during …

Antimicrobial Resistance of Streptococcus pneumoniae in Russia over the 1999–2009: Results of Multicenter Prospective Study PEHASus

Objective. To assess antimicrobial resistance and its trends among Streptococcus pneumoniae in different regions of Russia over the 1999-2009. Materials and Methods. A total of 2419 S. pneumoniae strains from different cities of Central, NorthWestern, Southern, Volga, Ural, Siberia, Far-Eastern regions of Russia were included into the study over the period from 1999 to 2009. Susceptibility to 23 antimicrobials was determined using microdilution method according to Clinical and Laboratory Standards Institute (CLSI) guidelines.

Acute Bacterial Rhinosinusitis in Young Soldiers: Etiology, Susceptibility and Antimicrobial Therapy

The objectives of this study were to investigate etiology of acute bacterial rhinosinusitis (ABR) in young soldiers, to determine susceptibility to different antimicrobial agents and to assess clinical efficacy of antimicrobial therapy in ABR. …