Streptococcus pneumoniae

Objective. Due to high activity against Streptococcus pneumoniae ceftaroline fosamil (CF) presents a good option for the treatment of adults with pneumococcal communityacquired pneumonia (PCAP) requiring parenteral antibacterial therapy. We aimed to assess cost-effectiveness of CF for the treatment of PCAP in a multi-field hospital in Russia from a societal perspective. Materials and Methods. Decision tree model based on the results of two 3rd phase clinical trials (FOCUS 1, FOCUS 2) was created to represent a standard approach to the management of hospitalised patients with PCAP and estimated outcomes including possible recurrence of infection, direct and delayed attributive mortality in case of initial therapy with CF 600 mg BID vs.

Streptococcus pneumoniae strains isolated from children of Krasnoyarsk (Siberia, Russian Federation) were examined. Authors determined Streptococcus pneumoniae serotypes and antimicrobial resistance. 16.7% of strains were multiple resistant with high …

The techniques for PCR-based identification and serotyping of Streptococcus pneumoniae were optimized for using in Russian epidemiologic situation. One hundred and thirteen strains isolated from children under 5 years of age in 15 Russian cities were …

Antimicrobial susceptibility, serotype distribution, and multilocus sequence types of Streptococcus pneumoniae isolated from the patients with meningitis were determined. We tested a total of 84 isolates which have been obtained in Moscow during …

Objective. To assess antimicrobial resistance and its trends among Streptococcus pneumoniae in different regions of Russia over the 1999-2009. Materials and Methods. A total of 2419 S. pneumoniae strains from different cities of Central, NorthWestern, Southern, Volga, Ural, Siberia, Far-Eastern regions of Russia were included into the study over the period from 1999 to 2009. Susceptibility to 23 antimicrobials was determined using microdilution method according to Clinical and Laboratory Standards Institute (CLSI) guidelines.

The objectives of this study were to investigate etiology of acute bacterial rhinosinusitis (ABR) in young soldiers, to determine susceptibility to different antimicrobial agents and to assess clinical efficacy of antimicrobial therapy in ABR. …

Objective. Objective: To assess the level, structure and phenotypes of antimicrobial resistance of Streptococcus pneumoniae in different regions of Russia and to evaluate their dynamics in period from 1999 to 2005. Materials and Methods. A total of 1704 S. pneumoniae from 23 cities of Central, North-Western, Southern, Privolgsk, Ural, Siberian and Far-Eastern regions of Russia were included into the study from 1999 to 2005. Susceptibility to 17 antimicrobials was determined by microdilution in accordance with Clinical and Laboratory Standards Institute/National Committee for Clinical Laboratory Standards (CLSI/NCCLS).

To understand the relationship between drug dose and efficacy, pharmacokinetic (PK) and pharmacodynamic (PD) characteristics need to be integrated. There are two patterns of antimicrobial activity: time-dependent killing and concentration-dependent …

This paper presents data on epidemiology and etiology of sinusitis in Russia as well as antimicrobial susceptibility patterns of most likely pathogens, causing different forms of the disease. Choice of antimicrobials for treatment of different types …

Objective. To determine the structure of antimicrobial resistance of clinical isolates of pneumococci in different regions of Russia. Materials and Methods. A total of 210 Streptococcus pneumoniae strains isolated in 15 centres of Central (Moscow – 5 centers, Kazan, Nizniy Novgorod, Ryzan), North-Western (Smolensk, Saint-Petersburg), Southern (Krasnodar) regions, Urals (Ekaterinburg) and Siberia (Novosibirsk, Tomsk) were included in this study. Susceptibility to 19 antimicrobials – penicillin G, amoxicillin, amoxicillin/clavulanate, cefotaxime, cefepime, erythromycin, azithromycin, clarithromycin, midecamycin, midecamycin acetate, spiramycin, clindamycin, tetracycline, ciprofloxacin, levolfloxacin, chloramphenicol, co-trimoxazole, rifampicin and vancomycin – was determined by broth microdilution in accordance with NCCLS recommendations.