resistance

Objective. To estimate proportion of hard and surrogate endpoints used as effectiveness criteria in pharmacoeconomic studies of antimicrobial drugs. Materials and Methods. The pharmacoeconomic studies of 30 antimicrobial agents proposed for inclusion in the Russian essential drug list in the 2014-2016 were reviewed. Results. A total of 47 effectiveness criteria were analyzed, of them 40.4% were hard endpoints. Two studies of antifungal drugs used the hard endpoints only. The hard endpoints were used in 58.

Mycoplasma pneumoniae is a bacterial pathogen cause of upper and lower respiratory tract infections, transmitted by airborne droplets, causing outbreaks of pneumonia mainly in closed groups. According with recommendations, M. pneumoniae infections …

Objective. To assess an incidence rate of carbapenemase-producing Gram-negative bacteria isolated from patients in the RRCRST. Materials and Methods. The clinical Gram-negative isolates obtained from patients hospitalized to the RRCRST over the period of February 2014 to April 2016 were tested. A screening for carbapenem resistance was performed by culture on chromogenic media, and species identification was made using MALDI-TOF massspectrometry. Susceptibility of Gram-negative bacteria to antimicrobial agents was determined using VITEK-2.

The resistance of the systemic Candida infections causative agents is a cornerstone of the selection of an effective therapy. But if before the problem was limited to resistance to azole antifungals, then by now we have enough data about cases of …

This paper presents data on in vitro activity of native honey against bacterial isolates with extreme resistance phenotypes. Comparison of antimicrobial activity of foreign honey preparations approved for the local treatment of infections with that …

The problem of genotypic variety of Acinetobacter baumannii isolated from patients with healthcare associated infections (HCAIs) are discussed. Carbapenemresistant strains, which are predominant in the study region, were shown to belong to the …

This study was performed to investigate activity of chlorhexidine-based antiseptic preparation «Dezin» against the following pathogens causing nosocomial respiratory tract infections (RTI) and urinary tract infections (UTI): Klebsiella pneumoniae …

Objective. Objectives. To analyze etiology and antimicrobial resistance of pathogens causing complicated community-acquired urinary tract infections (cUTI) in adult patients in different regions of Russia. Materials and Methods. Uropathogens isolated from urine samples of patients of both gender older than 18 years of age with community-acquired UTI were collected in 21 centers of 17 cities in Russia during 2010–2011 and included in the «DARMIS» study. Results. Among the collected 518 strains isolated from adult patients 282 strains (54,4%) were isolated from urine of patients with cUTI.

The changes in carbapenem consumption during 6 consecutive years have been studied in retrospective trial. 88% of carbapenems have been administered in the ICU’s and hematology department. The 3-fold increase of the total consumption during …

Currently, treatment of intra-abdominal infections is significantly complicated by increased antimicrobial resistance. Inappropriate antimicrobial therapy is one of the reasons for spread of extended spectrum beta-lactamases (ESBL) both in hospital …