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antibiotics

Consumption of systemic antibiotics in the Russian Federation in 2017–2021

Objective. To assess level and the structure of systemic antibiotic consumption in Russia over the period 2017 to 2021. Materials and Methods. Data were collected and analysed in compliance with the standard protocol of the World Health Organization Regional Office for Europe by the means of ATC/DDD methodology for J01 group – antibacterials for systemic use. Consumption was calculated for outpatients and inpatients separately as a number of DDDs per 1000 inhabitants per day (DID) for the main classes of antibiotics and the agents with the highest or the most diverse consumption levels for the given period of time, and was based on the data of wholesale purchases and public tenders.

Almost two years with COVID-19: some aspects of antibiotic use

The objective of this review was to summarize impact of the widespread administration of antibiotics in treatment algorithms for patients with COVID-19 on treatment outcomes. The experience of antimicrobial use agents during COVID-19 pandemic did not …

Antibiotics and community-acquired lower respiratory tract infections. To whom? Which one?

This paper discusses an etiology, patient characteristics, and antimicrobial resistance surveillance data, as well as other factors which help to determine indications for administration and choice of antibiotics for the treatment of patients with …

Mechanisms and regulation of antimicrobial resistance in Pseudomonas aeruginosa

Pseudomonas aeruginosa is a dangerous opportunistic pathogen. One of the most negative clinically significant features of P. aeruginosa is associated with the rapid acquisition of antimicrobial resistance. This review provides an analysis of current …

A pharmacoepidemiological study of patient-pharmacist interaction in antibiotics’ dispensing at a pharmacy

Self-treatment with antibiotics and their OTC-dispensing is one of the major problems associated with the inappropriate use of antibiotics. The study was aimed to identify the features of the behavior of patients and pharmacists in antibiotics’ …

Antibiotic dosing in obesity: size does matter?

Currently, from 15 to 50% of the population in the developed countries has obesity. Overall, patients with obesity have a higher risk of infection; they are more likely to develop infectious complications after surgical interventions and have a …

Medication errors associated with the use of cephalosporins

Objective. To discover the prevalence and types of medication errors associated with the use of cephalosporins through analysis of national spontaneous reporting database. Materials and Methods. We conducted a retrospective analysis of 2324 spontaneous reports concerning adverse drug reactions associated with the cephalosporins. All the reports were submitted to the Russian pharmacovigilance database between 01.01.2012 and 01.08.2014. Approved prescribing drug information, standards of medical care and practical guidelines for certain conditions were used to identify medication errors associated with specific products.

Responsible Use of Antibiotics in Food Animals

Antimicrobial use in food animal medicine has become an important political and scientific issue, especially in relation to the contribution that animal sourced antimicrobial resistance might play in human medicine, leading to calls at a political …

Characteristics of Enterobacteriaceae Strains Producing CTX-M type ESBL in a Cardiac Surgery Hospital

The study of the prevalence of ESBL CTX-M type of nosocomial strains of Enterobacteriaceae was perfomed. CTX-M enzymes have been identified in all ESBLproducing strains of Enterobacteriaceae. Identified β-lactamases belonged to the four genetic …

Safety and Efficacy of Antibiotics Used in Outpatient Setting

There are many antibiotics from various chemical classes available in drug armamentarium for the treatment of community-acquired infections at out-patient basis. In such cases safety and tolerability of administered treatment is of no less importance …