Some issues of safety of antimicrobial therapy in COVID-19 patients

Clinical Microbiology and Antimicrobial Chemotherapy. 2022; 24(3):226-235

​ Karoli N.A., Rebrov A.P.
10.36488/cmac.2022.3.226-235
COVID-19 antibiotics antimicrobial resistance C difficile
Section
Antimicrobials
Type
Review
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2022; 24(3):226-235

Abstract

Currently, there is a lack of evidence for empiric use of antimicrobial agents in most patients with COVID-19 in outpatient and hospital settings as the overall proportion of secondary bacterial infections in COVID-19 is quite low. This literature review summarizes data on changes in antimicrobial resistance over the course of COVID-19 pandemic, especially in nosocomial ESKAPE pathogens. The other significant consequences of excessive and unnecessary administration of antibiotics to COVID-19 patients including risk of Clostridioides difficile infection and adverse effects of antimicrobial agents are also discussed.

Nina A. Karoli

Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia

Rebrov A.P.

Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia

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