Antimicrobial Resistance of Nosocomial Enterobacteriaceae Isolates in Russia: Results of National Multicenter Surveillance Study «MARATHON» 2011–2012

Clinical Microbiology and Antimicrobial Chemotherapy. 2014; 16(4):254-265

​ Sukhorukova M.V., Edelstein M.V., Skleenova E.Yu., Ivanchik N.V., Timokhova A.V., Shek E.A., Dekhnich A.V., Kozlov R.S., «MARATHON» Study Group
Enterobacteriaceae E. coli K. pneumoniae antimicrobial resistance nosocomial infections
Section
Antimicrobial Resistance
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2014; 16(4):254-265

Abstract

Species of the family Enterobacteriaceae represent the most prevalent group of nosocomial pathogens. In this paper, we report the data on antimicrobial susceptibility of 573 isolates of Enterobacteriaceae collected in 25 hospitals of 18 cities of Russia in 2011–2012 as part of the national multicenter surveillance study on antimicrobial resistance of nosocomial pathogens, «MARATHON». Enterobacteriaceae isolates jointly comprised 33.7% of all bacterial nosocomial isolates. The most abundant species were Klebsiella pneumoniae (16.9%), Escherichia coli (7.9%) and Enterobacter cloacae (2.6%). Most of the isolates were insusceptible to oxyimino-b-lactams: cefotaxime (83.8%), ceftazidime (81.3%), cefepime (79.1%) and aztreonam (80.6%). Production of extended-spectrum b-lactamases (ESBLs) was detected in 78.2% of all isolates, including 90.6% of K. pneumoniae and 82.1% of E. coli. The non-susceptibility rates to carbapenems were: 2.8% to meropenem, 8.4% to imipenem and 14.0% to etrapenem. The majority of carbapenem resistant isolates were K. pneumoniae. 3.7% of all isolates were found to produce carbapenemases of OXA-48 – (3.3%) and NDM-1-group (0.4%). Most of the isolates were insusceptible to tobramycin (74.0%), gentamicin (60.4%), ciprofloxacin (70.5%) and trimethoprim-sulfamethoxazole (63.7%). Among non-b-lactam agents, the lowest resistance rates were observed with fosfomycin (14.1%), tigecycline 15,9%, colistin (16.1%) and amikacin (36,1%). Notably, 11.7% of the isolates were categorised as extensively drug-resistant (XDR).

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