Clinical Microbiology and Antimicrobial Chemotherapy. 2004; 6(2):133-142
Evidence-based analysis of clinical trials, concerning appropriateness of corticosteroids use and its efficacy in the treatment of septic shock, was performed. Results of pharmacoepidemiological study of corticosteroids use in Russian hospitals are presented. Author highlhts that empirical and disorderly prescribing prednisolone and dexamethasone to the patients with septic shock should be discouraged. Taking into account currently available evidence-based data on this topic, it is recommended to use only hydrocortisone at dose of 300 mg/day in the following subpopulations: patients with refractory septic shock or requiring for high-dose vasopressor support.