septic shock

Objective. To identify associations between functional polymorphisms in genes of the immune, endothelial, and coagulation systems and the severity and outcomes of sepsis to validate genetic risk predictors. Materials and Methods. This single-center prospective study included 124 patients aged of 1 month to 28 years with hematological malignancies, in whom 152 cases of sepsis were recorded. Genotyping of 20 polymorphic variants in 16 genes was performed using capillary Sanger sequencing.

Sepsis is a life-threatening condition resulting from a dysregulated immune response to infection and characterized by multiple organ dysfunction. Historically, the contribution of viruses to sepsis pathogenesis has been underestimated, largely due …

The present article represents an overview and critical analysis of new international clinical guidelines on the management of patients with severe sepsis and septic shock that were prepared with involvement of 15 medical associations, united for …

Reproduced with permission from the Society of Critical Care Medicine, the European Society of Intensive Care and Medicine and the International Sepsis Forum.

Evidence-based analysis of clinical trials, concerning appropriateness of corticosteroids use and its efficacy in the treatment of septic shock, was performed. Results of pharmacoepidemiological study of corticosteroids use in Russian hospitals are …