Comparative Activity of Antipseudomonal Antibiotics Against Nosocomial Strains of P. aeruginosa in Russian ICUs

Clinical Microbiology and Antimicrobial Chemotherapy. 2003; 5(1):35-46

Journal article


In vitro susceptibility study of nosocomial strains of Pseudomonas aeruginosa isolated from patients with nosocomial infections in 21 Russian ICUs was performed. Antibiotics with antipseudomonal activity, such as piperacillin, piperacillin/tazobactam, ceftazidime, imipenem, meropenem, gentamicin, amikacin, ciprofloxacin were tested. The most active against tested P. aeruginosa isolates were meropenem, amikacin, ceftazidime. Rates of non-susceptibility to these antimicrobial agents were 3.0, 6.3 and 12.2%, respectively. The less active antibiotics were imipenem and ciprofloxacin, to which rates of non-susceptibility were 22.9 and 32.8, respectively. The least active antipseudomonal drug was gentamicin; 73.9% of tested P. aeruginosa isolates were non-susceptible. In this study, rates of non-susceptibility of P. aeruginosa to piperacillin and piperacillin/tazobactam were 56.5 and 37.7%, respectively.

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