Clinical Microbiology and Antimicrobial Chemotherapy. 2003; 5(1):35-46
In vitro susceptibility study of nosocomial strains of Pseudomonas aeruginosa isolated from patients with nosocomial infections in 21 Russian ICUs was performed. Antibiotics with antipseudomonal activity, such as piperacillin, piperacillin/tazobactam, ceftazidime, imipenem, meropenem, gentamicin, amikacin, ciprofloxacin were tested. The most active against tested P. aeruginosa isolates were meropenem, amikacin, ceftazidime. Rates of non-susceptibility to these antimicrobial agents were 3.0, 6.3 and 12.2%, respectively. The less active antibiotics were imipenem and ciprofloxacin, to which rates of non-susceptibility were 22.9 and 32.8, respectively. The least active antipseudomonal drug was gentamicin; 73.9% of tested P. aeruginosa isolates were non-susceptible. In this study, rates of non-susceptibility of P. aeruginosa to piperacillin and piperacillin/tazobactam were 56.5 and 37.7%, respectively.