meropenem

Objective. To study pharmacodynamics of meropenem alone and in combination with avibactam in an in vitro dynamic model; to evaluate effectiveness of meropenem against K. pneumoniae strains producing and not producing carbapenemases; to study impact of bacterial inoculum on meropenem activity and its effects. Materials and Methods. K. pneumoniae producing KPC and OXA-48 carbapenemases and non-producing strains were exposed to meropenem or its combination with avibactam (carbapenemase-producing strains only) in a modified in vitro hollow-fiber infection model (pneumoniae) simulating human pharmacokinetics of drugs administrated thrice daily for 5 days.

Objective. To evaluate in vitro activity of biapenem and other clinically available carbapenems against Russian clinical isolates of Enterobacterales, Pseudomonas aeruginosa и Acinetobacter spp., including isolates with acquired fermentative mechanisms of resistance to β-lactams. Materials and Methods. A total of 3139 Enterobacterales isolates, 793 P. aeruginosa isolates and 634 Acinetobacter spp. isolates from hospitalized patients in 63 hospitals from 35 Russian cities were included in the study during 2018-2019. Minimal inhibitory concentrations (MIC) for biapenem and other antimicrobials were determined in accordance with ISO 20776-1:2006.

Introduction. In the conditions of dramatic rising of antibacterial resistance of gram-negative nosocomial pathogens, carbapenems plays a leading part as empiric antibacterial therapy, particularly in severe infections. Carbapenems on Russian pharmaceutical market presented by the original products and the number of generics from the India and other countries. Objective. The aim of the study was to compare the quality of original meropenem product and one of the generics. Materials and Methods.

Carbapenems are the most appropriate antimicrobials for empiric and pathogen-directed monotherapy in most severe and life-threatening infections in pediatric patients. It can be explained by broadest spectrum of activity, including multidrug …

The carbapenems are one of the most important classes of antimicrobial agents with an exceptionally broad spectrum of in vitro activity in association with low toxicity and beneficial pharmacokinetic parameters. Spectrum of activity of imipenem, …

Carpabenems (imipenem, meropenem, ertapenem) are currently one of the antibiotic classes that exhibit the broadest spectrum of activity and characterized by the low resistance rates of clinically significant pathogens. This article is an attempt to …

This paper presents analysis of microbiological, clinical and pharmacoeconomic studies of carbapenems. Use of carbapenems during the last two decades was not associated with emergence of resistance to these agents among clinically significant human …

In vitro susceptibility study of nosocomial strains of Pseudomonas aeruginosa isolated from patients with nosocomial infections in 21 Russian ICUs was performed. Antibiotics with antipseudomonal activity, such as piperacillin, …