Clinical Microbiology and Antimicrobial Chemotherapy. 2001; 3(4):324-338
The widespread of multy-resistant Gram-positive pathogens, especially methicillin-resistant staphylococci made us to reconsider our attitude to such an «old» drug as fusidic acid and to draw attention to its usefulness in therapy of the infection caused by these microorganisms. In present review the information on chemical and physical properties, antimicrobial activity, mechanism of action, pharmacokinetic, pharmacodynamic, clinical indications, clinical efficacy and spectrum of possible adverse drug reactions of fusidic acid is given. Pharmacological profile, safety, low level of resistance, absence of cross-resistance with other antimicrobials and possibility of step therapy allow to recommend fusidic acid to more frequent clinical use, especially in infections caused by methicillin-resistant strains Staphylococcus aureus.