Diseases and Pathogens

Over the last years, short treatment courses for different infections, including respiratory tract infections, are increasingly more discussed. This therapeutic approach has some clear benefits: improved compliance, less frequent adverse drug …

Onychomycosis is a fungal infection of nails of fingers of the hands or feet, resulting in thinning, and the subsequent destruction, discoloration and desquamation of the nail plate from the nail bed. The etiology of onychomycosis in most cases are …

Diabetic foot infections (DFIs) are a frequent clinical problem. Properly managed, most of them can be cured, but many patients needlessly undergo amputations because of improper diagnostic and therapeutic approaches. Foot infection should be defined …

The article contains modern notions of epidemiology, course, clinical and diagnostic aspects of communityacquired pneumonia caused by Mycoplasma pneumoniae, standards of its treatment and antibiotic resistance of this pathogen in the world …

Currently, HACEK group bacteria are a causative agent in 3% of infectious endocarditis cases; of which Aggregatibacter actinomycetemcomitans is the most frequent pathogen. However, this pathogen can be obtained from patients with meningitis, brain …

This paper represents a review of currently available data on microbial communities and biofilms as an important clinical problem. Structure and morphology of microbial biofilm as well as stages and mechanisms of its formation, and genes and factors …

Objective. To conduct a cost-effectiveness analysis of combination of azithromycin with b-lactams (cefotaxime, ceftriaxone or amoxicillin/clavulanic acid) vs levofloxacin in hospitalized adults with community-acquired pneumonia (CAP). Materials and Methods. We performed standard search and meta-analysis of prospective clinical trials (CT) to compare clinical success rate and tolerability of regimens of antibacterial therapy (ABT) under the investigation. Direct medical costs (DC) including cost of ABT and hospital stay were calculated from the perspective of Smolensk Regional Clinical Hospital and Central Clinical Hospital of Russian Academy of Sciences.

Objective. To reveal molecular types of nosocomial and community-acquired strains of S. aureus in different regions of Russia. Materials and Methods. 575 (187 MRSA and 388 MSSA) strains, isolated from pediatric patients during multicenter studies (1997–2008) from 36 medical institutions in 24 Russian cities were included in the study. For molecular typing 186 strains with unique resistance profile within each ward of each medical institution were selected. The following typing methods were used: MLVA, spa, SCCmec and MLST.

Long-term dialysis therapy in patients with chronic kidney disease is usually associated with vascular access problems, mechanic and infectious complications from the use intravascular devices, and increase in antimicrobial resistance. This paper …

Objective. To determine significance of Legionella pneumonia for hematological patients in ICUs, and to evaluate prospects of the proposed algorithm for diagnosis of legionellosis. Materials and Methods. A total of 37 hematological ICU patients were assessed for legionellosis between December 2010 and February 2012. Bronchoalveolar lavage (BAL) fluid culture and Legionella urinary antigen test (rapid immunochromatographic assay) were used to diagnose legionellosis. Results. Diagnosis of legionellosis was confirmed in 4 (11%) patients, of which 3 had fatal outcome.