Etiology of Infective Endocarditis in Russia

Clinical Microbiology and Antimicrobial Chemotherapy. 2015; 17(1):4-10

​ Danilov A.I., Alekseeva I.V., Asner T.V., Vlasova E.E., Danilova E.M., Dekhnich A.V., Drozdovich E.L., Eger Yu.V., Elokhina E.V., Kalyagin A.N., Kozlov R.S., Krechikova O.I., Litvinov A.V., Milyagin V.A., Mladov V.V., Ortenberg E.A., Palyutin Sh.H., Portnyagina U.S., Rog A.A., Trushin I.V., Fedorova O.B., Fominykh S.G., Shames D.V., Shpuntov M.G., Yakupova S.P.
infective endocarditis etiology antimicrobial resistance
Section
Diseases and Pathogens
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2015; 17(1):4-10

Objective.

To investigate etiology of infective endocarditis in Russian Federation.

Materials and Methods.

Multicenter prospective (September 2011 to December 2013) and retrospective (January 2006 – September 2011) studies to investigate etiology of infective endocarditis (IE) were performed at medical institutions in 10 Russian cities. Patients with definite or possible diagnosis of IE who have at least 1 blood culture collected were enrolled in the study.

Results.

A total of 401 patients with IE were included in the analysis: 161 (40.1%) prospective cases and 240 (59.9%) retrospective cases. Probable pathogens were isolated from 145 patients (36.2%). Gram-positive bacteria were the most prevalent pathogens – 88.3% (n=125), specifically Staphylococcus aureus (46.2% of all isolates). Methicillin resistance was found in 28.4% (19⁄67) of S. aureus isolates and 38.1% (8⁄21) of coagulasenegative staphylococci. Most enterococci isolates were resistant to gentamicin (61.9%).

Conclusions.

Gram-positive bacteria are the most common pathogens in patients with IE in Russian Federation, with S. aureus as a predominant one. The high beta-lactam and aminoglycoside resistance rates in staphylococci and enterococci, respectively, would make it difficult to select appropriate therapy for IE.

Andrey I. Danilov

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Alekseeva I.V.

Republic Hospital #2 – Center for Emergency Medical Care, Yakutsk, Russia

Asner T.V.

Irkutsk State Medical University, Irkutsk, Russia

Vlasova E.E.

City Clinical Hospital #15 named after O.M. Filatov, Moscow, Russia

Danilova E.M.

Children Outpatient Clinic #4, Smolensk, Russia

Andrey V. Dekhnich

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Drozdovich E.L.

Northern State Medical University, Arkhangelsk, Russia

Eger Yu.V.

Clinical Emergency Care Hospital, Smolensk, Russia

Elokhina E.V.

Omsk Regional Clinical Hospital, Omsk, Russia

Kalyagin A.N.

Irkutsk State Medical University, Irkutsk, Russia

Roman S. Kozlov

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Olga I. Krechikova

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Alexander V. Litvinov

Smolensk State Medical University, Smolensk, Russia

Milyagin V.A.

Smolensk State Medical University, Smolensk, Russia

Mladov V.V.

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Eduard A. Ortenberg

Tyumen State Medical Academy, Tyumen, Russia

Palyutin Sh.H.

Yaroslavl State Medical Academy, Yaroslavl, Russia

Portnyagina U.S.

Republic Hospital #2 – Center for Emergency Medical Care, Yakutsk, Russia

Rog A.A.

City Clinical Hospital #15 named after O.M. Filatov, Moscow, Russia

Ivan V. Trushin

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Fedorova O.B.

Hospital named after N.N. Semashko, Moscow, Russia

Stella G. Fominykh

Omsk State Medical Academy, Omsk, Russia

Shames D.V.

Kazan State Medical University, Kazan, Russia

Shpuntov M.G.

Smolensk State Medical University, Smolensk, Russia

Yakupova S.P.

Kazan State Medical University, Kazan, Russia

  • 1. Hoen B., Alla F., Selton-Suty C., Beguinot I., et al. Changing profile of infective endocarditis: results of a 1-year survey in France. JAMA 2002; 288:75-81.
  • 2. Hogevik H., Olaison L., Andersson R., Lindberg J., Alestig K. Epidemiologic aspects of infective endocarditis in an urban population. A 5-year prospective study. Medicine (Baltimore) 1995; 74:324-39.
  • 3. Moreillon P., Que Y.A. Infective endocarditis. Lancet 2004; 363:139-49.
  • 4. Friedman N.D., Kaye K.S., Stout J.E., McGarry S.A., et al. Health care-associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections. Ann Intern Med 2002; 137:791-7.
  • 5. Durack D. T., Lukes A. S., Bright D. K. New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings. Duke Endocarditis Service. Am J Med 1994; 96:200-9.
  • 6. Чипигина Н. С., Белостоцкий А. В. Инфекционный эндокардит: изменение предрасполагающих факторов и эволюция возбудителей. Сердце: журнал для практикующих врачей 2010; 9(4):242-50.
  • 7. Cabell C., Jollis J., Peterson G. et al. Changing patient characteristics and the effect on mortality in endocarditis. Arch Intern Med 2002:162(1):90-4.
  • 8. Li J. S., Sexton D. J., Mick N., Nettles R., et al. Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis 2000; 30:633-8.
  • 9. Habib G., Hoen B., et al. Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (new version 2009). Eur Heart J 2009; 30:2369-413.
  • 10. Baddour L., Wilson W., Bayer A., et al. Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: a statement for healthcare professionls from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association: endorsed by the Infectious Diseases Society of America. Circulation 2005; 111:e394-434.
  • 11. Murdoch D. R., Corey G. R., Hoen B., Miro J. M., et al. Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study. Arch Intern Med 2009; 169:463-73.
  • 12. Fitzsimmons K., Bamber A., Smalley H. Infective endocarditis: changing aetiology of disease. Br J Biomed Sci 2010; 67(1):35-41.
  • 13. Моисеев В.С., Котова Е. О., Караулова Ю.Л. Эпидемиология и клиническое течение современного инфекционного эндокардита (по данным муниципальной больницы). Клин фармакол тер 2014; 23(3):62-6.
  • 14. Николаевский Е. Н., Хубулава Г. Г., Шустов С. Б. Современные этиологические аспекты инфекционного эндокардита. Клин микробиол антимикроб химиотер 2006; 8(2):31.
  • 15. Тюрин В. П. Современные подходы к терапии инфекционного эндокардита. Сердце: журнал для практикующих врачей 2010; 9(5):307-12.
  • 16. Wisplinghoff H., Bischoff T., Tallent S., Seifert H., Wenzel R., Edmond M. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis 2004; 39: 309-17
  • 17. Luzzaro F., Ortisi G., Larosa M., Drago M., Brigante G., Gesu G. Prevalence and epidemiology of microbial pathogens causing bloodstream infections: results of the OASIS multicenter study. Diagn Microbiol Infect Dis 2011; 69: 363-69.
  • 18. Morpeth S., Murdoch D., Cabell C. H., Karchmer A. W. Non-HACEK gram-negative bacillus endocarditis. Ann Intern Med 2007; 147(12):829-35.
  • 19. Das M., Badley A. D., Cockerill F. R., Steckelberg J. M., Wilson W. R. Infective endocarditis caused by HACEK microorganisms. Ann Rev Med 1997; 48:25-33.
  • 20. Brouqui P., Raoult D. Endocarditis due to rare and fastidious bacteria. Clin Microbiol Rev 2001; 14(1):177- 207.
  • 21. Prendergast B. The changing face of infective endocarditis. Heart 2006; 92:879-85.
  • 22. Cosgrove S.E., Qi Y., Kaye K.S., Harbarth S., Karchmer A.W., Carmeli Y. The impact of methicillin resistance in Staphylococcus aureus bacteremia on patient outcomes: mortality, length of stay, hospital charges. Infect Control Hosp Epidemiol 2005; 26(2):166-74.
Views
0 Abstract
0 PDF
0 Crossref citations
Shared