Clinical Microbiology and Antimicrobial Chemotherapy. 2015; 17(1):4-10
To investigate etiology of infective endocarditis in Russian Federation.
Multicenter prospective (September 2011 to December 2013) and retrospective (January 2006 – September 2011) studies to investigate etiology of infective endocarditis (IE) were performed at medical institutions in 10 Russian cities. Patients with definite or possible diagnosis of IE who have at least 1 blood culture collected were enrolled in the study.
A total of 401 patients with IE were included in the analysis: 161 (40.1%) prospective cases and 240 (59.9%) retrospective cases. Probable pathogens were isolated from 145 patients (36.2%). Gram-positive bacteria were the most prevalent pathogens – 88.3% (n=125), specifically Staphylococcus aureus (46.2% of all isolates). Methicillin resistance was found in 28.4% (19⁄67) of S. aureus isolates and 38.1% (8⁄21) of coagulasenegative staphylococci. Most enterococci isolates were resistant to gentamicin (61.9%).
Gram-positive bacteria are the most common pathogens in patients with IE in Russian Federation, with S. aureus as a predominant one. The high beta-lactam and aminoglycoside resistance rates in staphylococci and enterococci, respectively, would make it difficult to select appropriate therapy for IE.