Аннотация
Исследования последних десятилетий убедительно подтвердили пользу для здоровья пробиотических микроорганизмов. Однако в настоящее время есть целый ряд вопросов о пробиотиках, которые пока либо остаются без ответов, либо ответы на них не всегда однозначны. В данной статье с позиций доказательной медицины освещены нерешенные или неясные на текущий момент вопросы, в частности, касающиеся регуляторного статуса пробиотиков, возможности их назначения совместно с антибиотиками, влияния использования пробиотиков на риск развития и распространения антибиотикорезистентности, подходов к дозированию и длительности применения пробиотиков, противопоказаний, и некоторые другие спорные аспекты их применения.
ФГБОУ ВО «Смоленский государственный медицинский университет» Минздрава России, Смоленск, Россия
НИИ антимикробной химиотерапии ФГБОУ ВО СГМУ Минздрава России, Смоленск, Россия
НИИ антимикробной химиотерапии ФГБОУ ВО СГМУ Минздрава России, Смоленск, Россия
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