Конъюгаты сидерофоров с антибиотиками: структурное разнообразие и антибактериальная активность

Клиническая микробиология и антимикробная химиотерапия. 2022; 24(4):314-344

​ Чернышов В.В., Кузовлев А.С., Черепанова Н.Д., Касаткина М.А., Иванов Р.А.
10.36488/cmac.2022.4.314-344
сидерофоры конъюгаты сидерофор­антибиотик сидеромицины антибиотикорезистентность антибактериальная активность
Раздел
Антимикробные препараты
Тип
Обзор
Публикация
Клиническая микробиология и антимикробная химиотерапия. 2022; 24(4):314-344

Аннотация

В связи с неконтролируемым ростом устойчивости микроорганизмов к действию современных противомикробных препаратов возникают опасения, что в недалеком будущем человечество может вернуться в «доантибиотическую эру», когда даже для ранее легко излечимых инфекционных заболеваний не будет существовать надежных режимов антимикробной терапии. Одним из способов решения данной проблемы является лечение инфекционных заболеваний, вызванных антибиотикорезистентными бактериальными штаммами, с использованием направленной доставки антибиотиков с помощью конъюгации последних с сидерофорами (малыми молекулами, секретируемыми микроорганизмами для поглощения жизненно необходимого Fe(III)). Модифицированный сидерофором антибиотик (сидеромицин), подобно Троянскому коню, поглощается бактериальной клеткой в виде комплекса с Fe(III), позволяя антибиотику достигнуть своей биологической мишени. В данной работе рассмотрено структурное разнообразие конъюгатов сидерофоров с антибиотиками, в первую очередь, с фокусом на строение сидеромицина, во вторую – на взаимосвязь структуры сидеромицина и его антибактериальной активности. Настоящая работа состоит из двух основных частей: в первой кратко рассмотрены основные представители различных классов сидерофоров; во второй части демонстрируется структурное разнообразие сидеромицинов и подробно обсуждается их антибактериальная активность.

Владимир Владимирович Чернышов

АНО ВО «Научно-технологический университет «Сириус», Краснодарский край, Россия

Кузовлев А.С.

АНО ВО «Научно-технологический университет «Сириус», Краснодарский край, Россия

Черепанова Н.Д.

АНО ВО «Научно-технологический университет «Сириус», Краснодарский край, Россия

Касаткина М.А.

АНО ВО «Научно-технологический университет «Сириус», Краснодарский край, Россия

Иванов Р.А.

АНО ВО «Научно-технологический университет «Сириус», Краснодарский край, Россия

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