Инновационные антибиотики для системного применения | КМАХ

Инновационные антибиотики для системного применения

Клиническая Микробиология и Антимикробная Химиотерапия. 2015; 17(4):272-285

​ Решетько О.В., Якимова Ю.Н.
разработка лекарственных средств новые антимикробные препараты
Раздел
Антимикробные препараты
Тип
Журнальная статья
Публикация
Клиническая Микробиология и Антимикробная Химиотерапия. 2015; 17(4):272-285

Аннотация

Одним из путей решения проблемы резистентности микроорганизмов к антимикробным препаратам является создание новых более эффективных антибиотиков, обладающих новыми механизмами действия. В статье приведён обзор инновационных антибиотиков, находящихся на разных стадиях доклинического и клинического исследования, в отношении которых подразумевается возможность их практического применения в дальнейшем. В настоящее время в активной разработке находится несколько десятков новых антибиотиков. Разработки ведутся как в направлении модификации уже известных групп антибактериальных препаратов (β-лактамные антибиотики, макролиды, тетрациклины, полипептидные антибиотики), так и в области поиска веществ с новыми механизмами действия (ингибиторы шаперона LolA, белка FtsZ и др.). Модификация структур известных препаратов приводит к формированию их новых подгрупп: бициклолидов (макролиды), фторциклинов, аминометилциклинов, пентациклинов (тетрациклины).

Решетько Ольга Вилоровна

ГБОУ ВПО «Саратовский государственный медицинский университет им. В.И. Разумовского» Минздрава России, Саратов, Россия

Якимова Ю.Н.

ГБОУ ВПО «Саратовский государственный медицинский университет им. В.И. Разумовского» Минздрава России, Саратов, Россия

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