Аннотация
Инвазивные микозы становятся все более актуальной проблемой практической медицины. Это связано с увеличением численности иммунокомпрометированных популяций пациентов. Несмотря на то, что основными возбудителями инвазивных микозов до сих пор остаются Candida albicans, Aspergillus fumigatus и Cryptococcus neoformans, растет число случаев системной грибковой инфекции, вызванной редкими мицелиальными грибами и не-albicans штаммами грибов рода Candida. Смена спектра возбудителей и высокая частота нежелательных явлений при использовании системных антимикотиков привели к потребности в создании новых противогрибковых препаратов, как в ряду уже существующих классов, так и путем создания новых химических структур. В статье рассмотрены основные представители новых антимикотиков для системного применения, сделана попытка их сравнительной характеристики, включая особенности их фармакокинетики, фармакодинамики, спектра активности, нежелательных явлений, а также перспектив применения в клинической практике.
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