S. aureus

Species diversity and methicillin resistance in Staphylococcus spp. in nosocomial infections

Objective. To evaluate Staphylococcus species diversity and methicillin resistance in nosocomial infections. Materials and Methods. Staphylococci isolated from blood, bronchoalveolar lavage fluid, cerebrospinal fluid, post-operative wound exudates, urine and other samples were identified to species level with MALDITOF mass-spectrometry. Methicillin resistance was evaluated according to EUCAST guidelines. Results. A total of 3239 consecutive Staphylococcus strains isolated in a tertiary-care medical centre, accumulating patients from all Russian regions were identified in 2016–2017 as 1460 (45.

Evidence Based Review on Daptomycin Use in the Treatment of Gram(+) Infections

Daptomycin is the only clinically used member of a cyclic lipopeptides class of antibiotics. Daptomycin has rapid bactericidal activity against not only rapidly growing, but also against slow growing bacterial cells including those in biofilms. …

Biofilm Formation by Clinical Isolates of S. aureus and S. epidermidis in Prosthetic Joint Infection

Objective. Objectives. In vitro study of biofilm forming capacity of S. aureus and S. epidermidis strains, most common etiological agents of PJI following orthopedic surgeries, depending on source of strain, species of etiological agent and methicillin susceptibility. Materials and Methods. 241 S. aureus and 153 S. epidermidis strains, isolated from the tissue biopsies, the join aspirates and removed orthopedic prosthesis in 2012 year from 321 patients with PJI were investigated.

Local Antimicrobial Resistance Profile as a Basis for the Choice of Antimicrobial Therapy of Staphylococcal Prosthetic Joint Infections

Objective. To determine the most effective antibiotics for therapy of infectious complications of prosthetic joint implantation caused by S. aureus and S. epidermidis. Materials and Methods. The antibiotic resistance profiles were determined for 535 clinical S. aureus and 211 S. epidermidis isolates. All the strains were isolated from the removed prosthesis and biological samples from patients with prosthetic joint infection (PJI). Susceptibility of clinical isolates was determined to 14 antibiotics according to EUCAST guidelines.

Antimicrobial Resistance among Bacterial Pathogens Causing Ocular Infections in Russia

Objective. To determine bacterial pathogens causing ocular infections and their antimicrobial susceptibility patterns. Materials and Methods. This prospective microbiological study included a total of 235 isolates of aerobic microorganisms obtained from 235 patients in 10 Russian regions. Susceptibility to the following antimicrobials (ampicillin, amoxicillin, amoxicillin/clavulanate, oxacillin, penicillin, ciprofloxacin, levofloxacin, moxifloxacin, ofloxacin, norfloxacin, tobramycin, gentamicin, chloramphenicol, polymyxin B, tetracycline, and erythromycin) was determined using serial dilution method. Results. The most predominant pathogens in ocular infections were S.

Daptomycin – the Review of Pharmacological, Clinical and Microbiological Characteristics

Daptomycin is the first approved member of a cyclic lipopeptides class of antibiotics with anti-Gram(+) activity. In contrast to majority of other antimicrobials daptomycin has rapid bactericidal activity against not only rapidly growing, but also …

Antimicrobial Resistance of S. aureus Isolated from Infants with Skin and Soft Tissue Infections

The most common pathogens of skin and soft tissue infections (SSTI) as well as pharmacodynamics parameters of different antimicrobials against S. aureus are considered in this paper. A total of 80 clinical S. aureus isolates obtained from children (0 …

Etiology of Diabetic Foot Infections and In Vitro Activity of Antimicrobial Agents

This article presents the results of the study to determine etiology and antimicrobial susceptibility in diabetic foot infections (DFI). A total of 288 isolates were obtained from patients with confirmed DFI by fine-needle aspiration/biopsy during …