respiratory tract infections

Penicillin/Beta-lactamase Inhibitor Combinations in the Treatment of Bacterial Respiratory Tract Infections in Children

Over the several decades, medical and pharmaceutical science has been trying to solve the problem of antimicrobial therapy inefficiency due to rapidly increasing antimicrobial resistance. One of the antimicrobial agents being capable to overcome the …

Paediatricians Approach to Prescribing of Systemic Antimicrobials in Outpatient Children with Upper Respiratory Tract and ENT Infections: Data from Multicenter Survey

Objective. Objectives. The study aimed to assess paediatricians knowledge of etiology and approach to systemic antimicrobials (АМ) use in outpatient children with acute respiratory tract infections. Materials and Methods. A questionnaire survey of primary care paediatricians from 17 cities of Russian Federation was performed in 2011–2013 in compliance with the unified methodology. Results. A total of 701 paediatricians (mean age 46,3±10,7, 61,5% with work experience >15 years) took part in the survey.

Oral Third-Generation Cephalosporins in Current Outpatient Clinical Practice

This paper presents current issues with the oral thirdgeneration cephalosporins in outpatient clinical practice. These data are based on the principles of appropriate antimicrobial therapy, national antimicrobial susceptibility data, and …

«Respiratory» Fluoroquinolones – the Neoclassics of Antimicrobial Chemotherapy

«Respiratory» fluoroquinolones, unlike previous generations, have higher activity against Gram-positive pathogens causing important infections in humans. Broad antimicrobial spectrum, ability to overwhelm some bacterial resistance mechanisms, absence …

The Management of Lower Respiratory Tract Infections in Adult Patients (Review of the 2011 ERS and ESCMID guidelines)

Previous edition of the joint guidelines of the European Respiratory Society and European Society of Clinical Microbiology and Infectious Disease on the management of lower respiratory tract infections in adult patients was published in 2005 and …

Respiratory Tract Infections: New View on the Old Problem

Respiratory tract infections are the most common human infectious diseases. These infections may cause serious complications and cause tremendous economic losses. Therefore the adequate treatment of different types of respiratory infections, …

New Approaches to the Optimization of Antimicrobial Therapy of Respiratory Tract Infections Using Pharmacokinetic and Pharmacodynamic Parameters

To understand the relationship between drug dose and efficacy, pharmacokinetic (PK) and pharmacodynamic (PD) characteristics need to be integrated. There are two patterns of antimicrobial activity: time-dependent killing and concentration-dependent …

Moxifloxacin – the New Fluoroquinolone with Broad Spectrum of Activity

Moxifloxacin – new broad spectrum 8-methoxyquinolon with high activity against Gram(+) and Gram(-) microorganisms as well as against anaerobes and intracellular pathogens. It is also active against microorganisms that are resistant to other classes …