MRSA

Objective. Objectives. In vitro study of biofilm forming capacity of S. aureus and S. epidermidis strains, most common etiological agents of PJI following orthopedic surgeries, depending on source of strain, species of etiological agent and methicillin susceptibility. Materials and Methods. 241 S. aureus and 153 S. epidermidis strains, isolated from the tissue biopsies, the join aspirates and removed orthopedic prosthesis in 2012 year from 321 patients with PJI were investigated.

Infectious complications are constitute a serious challenge for patients receiving hemodialysis. With regard to the broad spread of S. aureus isolates with lost susceptibility to β-lactams (MRSA) vancomycin is key option for treatment of these …

Siphoviridae family bacteriophages are known to play a major role in horizontal transfer of virulence genes among Staphylococcus aureus. Integrase group 3 phages transfer genes encoding staphylokinase (sak), staphylococcal complement inhibitor (scn), …

Bacteriological and clinical data on the novel cephalosporin antibiotic ceftarolin fosamil is reviewed. Ceftarolin may be considered as promising drug in Russia due to potent anti-MRSA and antipneumococcal activity, broad spectrum and low toxicity.

Objective. To determine the most effective antibiotics for therapy of infectious complications of prosthetic joint implantation caused by S. aureus and S. epidermidis. Materials and Methods. The antibiotic resistance profiles were determined for 535 clinical S. aureus and 211 S. epidermidis isolates. All the strains were isolated from the removed prosthesis and biological samples from patients with prosthetic joint infection (PJI). Susceptibility of clinical isolates was determined to 14 antibiotics according to EUCAST guidelines.

Objective. To reveal molecular types of nosocomial and community-acquired strains of S. aureus in different regions of Russia. Materials and Methods. 575 (187 MRSA and 388 MSSA) strains, isolated from pediatric patients during multicenter studies (1997–2008) from 36 medical institutions in 24 Russian cities were included in the study. For molecular typing 186 strains with unique resistance profile within each ward of each medical institution were selected. The following typing methods were used: MLVA, spa, SCCmec and MLST.

Since 1961, pandemic methicillin-resistant S. aureus (MRSA) clones causing severe nosocomial infections have been distributed worldwide. The Hungarian clone having ST239 genotype and Staphylococcal cassette chromosome mec (SCCmec) type III is one of …

Over the last decades there is an uncontrollable rise of MRSA prevalence. Infections caused by MRSA are associated with high mortality and healthcare costs. New antimicrobial drugs (anti-MRSA cephems, new glycopeptides, lipopeptides, glycilcyclines …

Objective. To determine in vitro activity of antimicrobials against S. aureus isolated from ICU patients in different regions of Russia. Materials and Methods. A total of 998 clinical strains of S.aureus isolated in 2004–2005 from 998 patients hospitalized in ICU of 32 medical institutions in different parts of Russia. Susceptibility to 16 antimicrobials was determined by agar dilution method in accordance with CLSI recommendations. Results. The prevalence of MRSA among tested strains was 49.

Objective. To determine in vitro activity of antimicrobials against S. aureus isolated from ICU patients in different regions of Russia. Materials and Methods. A total of 998 clinical strains of S.aureus isolated in 2004-2005 from 998 patients hospitalized in ICU of 32 medical institutions in different parts of Russia. Susceptibility to 16 antimicrobials was determined by agar dilution method in accordance with CLSI recommendations. Results. The prevalence of MRSA among tested strains was 49.