Abstract
Infectious complications are constitute a serious challenge for patients receiving hemodialysis. With regard to the broad spread of S. aureus isolates with lost susceptibility to β-lactams (MRSA) vancomycin is key option for treatment of these infections. However, conventional dosing protocol in this patients population is not sufficiently effective at present. It does not allow to achieve necessary trough serum vancomycin concentrations and to ensure pharmacodynamic conditions for successful eradication of MRSA with MIC of vancomycin ≥1 mg/l. New dosing protocol was developed and clinically validated recently
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