antimicrobials

Urinary tract infections (UTI) in patients with diabetes mellitus are considered complicated UTI. The specific characteristics of UTI in diabetic patients are the following: high prevalence of asymptomatic bacteriuria, involvement of upper urinary …

The objective of the study was to evaluate the outpatient use of systemic antimicrobials in different regions of Russia. Data on the use of antimicrobials in 24 regions of Russia during year 2004 were collected according to the audit of …

Translated and reprinted with permission from «Chemotherapie Journal» 2007; 16:41-8.

The main objective of this study was to compare the efficacy of levofloxacin in hospitalized patients suffering from pneumonia to other antibiotic options by …

Russia is the only country, where the term «dysbacteriosis» is used. However, there is no nosologic form such as dysbacteriosis in the ICIDH-10, and effectiveness of the medications used for prophylaxis and treatment of this condition has a lowest …

The problem of counterfeit drugs was first discussed at international level in 1985 at the World Health Organization Conference of Experts on the Rational Use of Drugs in Nairobi. Nowadays it is estimated that counterfeit arc up to 10% of allmarketed …

The use of antimicrobials in pregnancy is associated with a potential risk for deleterious effect on fetus and neonate. Pregnancy may be associated with changes in pharmacokinetics because of reduced renal blood flow and glomerular filtration, …

To understand the relationship between drug dose and efficacy, pharmacokinetic (PK) and pharmacodynamic (PD) characteristics need to be integrated. There are two patterns of antimicrobial activity: time-dependent killing and concentration-dependent …

This paper presents data on epidemiology and etiology of sinusitis in Russia as well as antimicrobial susceptibility patterns of most likely pathogens, causing different forms of the disease. Choice of antimicrobials for treatment of different types …

Most drugs and their metabolites are partly or completely excreted by kidneys. Thus in patients with renal impairment it is often crucial to modify antibiotic dosage regimens accordingly to the renal function tests. One of the main characteristics is …

The WHO Model List of Essential Drugs is eagerly awaited in many countries as a guide to what should be provided for basic health needs. Colloquially known as the «Essential Drugs List» it should perhaps be remembered that it is only a …