antimicrobials

New Approaches to the Optimization of Antimicrobial Therapy of Respiratory Tract Infections Using Pharmacokinetic and Pharmacodynamic Parameters

Clinical Microbiology and Antimicrobial Chemotherapy. 2004; 6(1):22-31

To understand the relationship between drug dose and efficacy, pharmacokinetic (PK) and pharmacodynamic (PD) characteristics need to be integrated. There are two patterns of antimicrobial activity: time-dependent killing and concentration-dependent …

Practice Guidelines on Antimicrobial Therapy of Sinusitis

Clinical Microbiology and Antimicrobial Chemotherapy. 2003; 5(2):167-174

This paper presents data on epidemiology and etiology of sinusitis in Russia as well as antimicrobial susceptibility patterns of most likely pathogens, causing different forms of the disease. Choice of antimicrobials for treatment of different types …

Dosage of antibioties in patients with renal impairment

Clinical Microbiology and Antimicrobial Chemotherapy. 2000; 2(2):86-92

Most drugs and their metabolites are partly or completely excreted by kidneys. Thus in patients with renal impairment it is often crucial to modify antibiotic dosage regimens accordingly to the renal function tests. One of the main characteristics is …

The WHO Model List of Essential Drugs

Clinical Microbiology and Antimicrobial Chemotherapy. 2000; 2(1):37-46

The WHO Model List of Essential Drugs is eagerly awaited in many countries as a guide to what should be provided for basic health needs. Colloquially known as the «Essential Drugs List» it should perhaps be remembered that it is only a …