Clinical Microbiology and Antimicrobial Chemotherapy. 2000; 2(2):86-92
Most drugs and their metabolites are partly or completely excreted by kidneys. Thus in patients with renal impairment it is often crucial to modify antibiotic dosage regimens accordingly to the renal function tests. One of the main characteristics is glomerular filtration rate that can be estimated on the base of creatinine clearance. This article provides the guidelines for dose and regimen adjustment of the most frequently prescribing antibiotics. Principles of antibiotic usage in patients on haemo- and peritoneal dialysis are also discussed.