Antimicrobial resistance of Neisseria gonorrhoeae in the Russian Federation: regional differences | CMAC

Antimicrobial resistance of Neisseria gonorrhoeae in the Russian Federation: regional differences

Clinical Microbiology and Antimicrobial Chemotherapy. 2017; 19(2):153-159

​ Solomka V.S., Kubanov A.A., Plakhova K.I., Chestkov A.V., Petrova N.P., Deryabin D.G.
Neisseria gonorrhoeae antimicrobial resistance NG-MAST regional differences
Section
Antimicrobial Resistance
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2017; 19(2):153-159

Objective.

To assess regional differences in antimicrobial susceptibility of N. gonorrhoeae in the Russian Federation.

Materials and Methods.

A total of 365 N. gonorrhoeae strains were isolated over the period of 2015-2016 in Arkhangelsk, Astrakhan, Bryansk, Kaluga, Novosibirsk, Omsk, Ryazan, Tomsk regions, Republic of Tatarstan and Chuvashiya Republic. Antimicrobial susceptibility testing was performed by agar dilution method and assessed according to MUK 4.2.1890-04 criteria using WHONET software (v5.4). Molecular typing was performed according to the NG-MAST protocol.

Results.

Russian isolates of N. gonorrhoeae were found to be highly susceptible to ceftriaxone and spectinomycin (100% and 98.9%, respectively) along with significantly different susceptibility to benzylpenicillin, tetracycline, ciprofloxacin, and azithromycin in several regions. Regional differences included a high prevalence of isolates susceptible to all of the antimicrobials tested in Chuvashiya (54.0%), Kaluga (64.1%) and Tomsk (77.8%) regions; in contrast, multidrug resistant isolates were the most common in Bryansk (30.4%) and Ryazan (46.2%) regions. Molecular typing showed a significant diversity of the current Russian population of N. gonorrhoeae. Specifically, the most prevalent sequence types were ST 807, 1993, 5714, which were found in most regions and susceptible to all of the antimicrobials tested. Multidrug resistant ST 4707, 12096, 14826 were less frequent and associated with the specific region of the Russian Federation.

Conclusions.

The significant heterogeneity of the Russian population of N. gonorrhoeae is a rationale for the development of regional supplements to the national list of antimicrobials recommended for the treatment of gonococcal infections. It requires a representativeness of the regional N. gonorrhoeae samples to be increased, as well as their antimicrobial susceptibility testing to be performed on a regular basis.

Solomka V.S.

State Scientific Center of Dermatology, Venerology and Cosmetology, Moscow, Russia

Kubanov A.A.

Russian Medical Academy of Continuous Professional Education, Moscow, Russia

Plakhova K.I.

State Scientific Center of Dermatology, Venerology and Cosmetology, Moscow, Russia

Chestkov A.V.

State Scientific Center of Dermatology, Venerology and Cosmetology, Moscow, Russia

Petrova N.P.

State Scientific Center of Dermatology, Venerology and Cosmetology, Moscow, Russia

Dmitry G. Deryabin

State Scientific Center of Dermatology, Venerology and Cosmetology, Moscow, Russia

  • 1. Unemo M. Current and future antimicrobial treatment of gonorrhoea – the rapidly evolving Neisseria gonorrhoeae continues to challenge. BMC Infect Dis. 2015; 15:364.
  • 2. WHO. 69th World Health Assembly. Draft global health sector strategies. Sexually transmitted infections, 2016-2021. Report by the Secretariat: А69/33; 16 May 2016.
  • 3. WHO Western Pacific Programme; South East Asian GASP, Tapsall J.W., et al. Surveillance of antibiotic resistance in Neisseria gonorrhoeae in the WHO Western Pacific and South East Asian regions, 2007-2008. Commun Dis Intell Q Rep. 2010; 34(1):1-7.
  • 4. http://www.who.int/reproductivehealth/topics/rtis/gasp_network/en/
  • 5. Kubanov A.A., Rahmatulina M.R., Solomka V.S., et al. Current trends in antimicrobial resistance of Neisseria gonorrhoeae in Russian Federation. Klinicheskaja mikrobiologija i antimikrobnaja himioterapija. 2016; 18(4):282-290. Russian.
  • 6. WHO. Department of Reproductive Health and Research: Global action plan to control the spread and impact of antimicrobial resistance in Neisseria gonorrhoeae. Geneva; 2012:1-36.
  • 7. Rahmatulina M.R. Gonococcal infection: approaches to diagnosis and therapy according to Russian and foreign clinical guidelines. Vestnik dermatologii i venerologii. 2015; 2:41-48. Russian.
  • 8. Federal clinical guidelines on the management of patients with gonococcal infection. Moscow: Russian Society of Dermatovenereologists and Cosmetologists, 2015. Russian.
  • 9. Sehin S.V., Voznesenskij D.L., Vasil’ev M.M., Kubanov A.A. Guidelines on antimicrobial susceptibility testing of Neisseria gonorrhoeae. Klinicheskaja mikrobiologija i antimikrobnaja himioterapija. 2003; 5(2)175-182. Russian.
  • 10. Antimicrobial Susceptibility Testing Guidelines: MUK 4.2.1890-04. Moscow, 2004. Russian.
  • 11. European centre for disease prevention and control. Molecular typing of Neisseria gonorrhoeae – results from a pilot study 2010-2011. Stockholm, ECDC, 2012.
  • 12. Kubanova A.A., Kubanov A.A., Frigo N.V., et al. Software for analysis and imaging of data on drug resistance and molecular typing in STD pathogens. Registration certificate #2014617611 dated July 29, 2014. Russian.
  • 13. Vorob’ev D.V., Solomka V.S., Plahova K.I., Derjabin D.G., Kubanov A.A. NGMAST genotyping of N. gonorrhoeae isolated in the Russian Federation in the 2012-2015. Zhurnal mikrobiologii, epidemiologii i immunobiologii. 2016; 4:42-50. Russian.
  • 14. Lebedzeu F., Golparian D., Titov L., et al. Antimicrobial susceptibility/ resistance and NG-MAST characterization of Neisseria gonorrhoeae in Belarus, Eastern Europe, 2010-2013. BMC Infect Dis. 2015; 15:29.
  • 15. Kushnir A.V., Muminov T.A., Bayev A.I., Khrapov E.A., Filipenko M.L. Molecular characterization of Neisseria gonorrhoeae isolates in Almaty, Kazakhstan, by VNTR analysis, Opa-typing and NG-MAST. Infect Genet Evol. 2012; 12:570-576.
Views
0 Abstract
0 PDF
0 Crossref citations
Shared