Antimicrobial resistance of nosocomial Enterobacteriaceae isolates in Russia: results of multicenter epidemiological study «MARATHON» 2013-2014

Clinical Microbiology and Antimicrobial Chemotherapy. 2017; 19(1):49-56

Journal article


Species of the family Enterobacteriaceae represent the most prevalent group of nosocomial pathogens. In this paper, we report the data on antimicrobial susceptibility of 1670 isolates of Enterobacteriaceae collected in 35 hospitals of 22 cities of Russia in 2013-2014 as part of the national multicenter surveillance study on antimicrobial resistance of nosocomial pathogens, «MARATHON». Enterobacteriaceae isolates jointly comprised 43.1% of all bacterial nosocomial isolates. The most abundant species were Klebsiella pneumoniae (20.7%), Escherichia coli (11.2%) and Enterobacter cloacae (2.6%). Most of the isolates were insusceptible to oxyimino-β-lactams: cefotaxime (75.6%), ceftazidime (71.9%), cefepime (72.0%) and aztreonam (72.5%). The non-susceptibility rates to carbapenems were: 6.9% to meropenem, 7.8% to doripenem, 8.5% to imipenem and 18.0% to ertapenem. The majority of carbapenem resistant isolates were K. pneumoniae. 7.8% of all isolates were found to produce carbapenemases of OXA-48 (6.3%) and NDM-1-group (1.6%). Only 1.9% и 2.6% were insusceptible to aztreonam/avibactam and ceftazidime/avibactam correspondingly. Among non-β-lactam agents, the lowest resistance rates were observed with amikacin (16.6%), colistin (18.8%), tigecycline (23.5%) and fosfomycin (28.2%). Notably, 1.1% of the isolates were categorised as extensively drug-resistant (XDR).

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