Clinical Microbiology and Antimicrobial Chemotherapy. 2016; 18(1):68-74
We studied 126 children, admitted to cardiac surgery hospital with colonization of the gastrointestinal tract (GIT) by multidrug-resistant Enterobacteriaceae. Criterion for inclusion in the study were children with complex congenital heart disease before the age of 1 year, with a previous hospitalization. Study was performed from April to December in 2013. In 51 (40.5%) patients colonization of the GIT by MDR-Enterobacteriaceae was detected. In 49 (38.9%) cases we revealed ESBL-producing strains using double-disk method. ESBL-producing strains expressed gene of CTX-M-1-related enzymes in 93% and gene of CTX-M-9-related enzymes in 6.8% cases. We revealed 10 cases of colonization GIT by carbapenem-resistant Enterobacteriaceae which expressed gene CTX–M-1- related enzymes (8 strains) and gene OXA-48 (2 strains). Detection of carbapenemase-producing K. pneumoniae was demonstrated the need of the strictest compliance with infection control measures and the introduction of modern methods of microbiological diagnosis.