Ceftibuten in the Treatment of Community-Acquired Urinary Tract Infections in Russia

Objective.

Objectives. To investigate etiology and in vitro susceptibility of the most common pathogens causing community-acquired urinary tract infections (UTIs) in Russia.

Materials and Methods.

A total of 182 uropathogens isolated from urine samples of patients with communityacquired UTI were collected in Russia during 2013–2014 and included in the study.

Results.

Among the identified microorganisms the most prevalent uropathogens were Enterobacteriaceae (87,9%) and E. coli (68,1%). Drugs active against more than 90% of all Enterobacteriaceae isolates were fosfomycin (98,1%) and ceftibuten (93,1%). Susceptibility rates to other tested β-lactams were at the range of 63,7% — 81,9%. Fluoroquinolones, nitrofurantoin and co-trimoxazole were active against 75% — 84% of all Enterobacteriaceae isolates. Out of tested antibiotics the most active against E. coli were again fosfomycin (99%), nitrofurantoin (98%) and ceftibuten (95%). Susceptibility of E. coli isolates to fluoroquinolones (ciprofloxacin and norfloxacin) was 78% and 81%, respectively. Susceptibility of E. coli to co-trimoxazole was 73%.

Conclusions.

Higher susceptibility rates of all Enterobacteriaceae and E. coli alone to fosfomycin and ceftibuten shown in this study enable the use of these antimicrobials in treatment of community-acquired UTI in Russia.