Pneumocystis and Herpesviruses in Immunocompromised Children

Clinical Microbiology and Antimicrobial Chemotherapy. 2015; 17(4):254-261

Type
Journal article

Objective.

Objectives. Study of the role of herpes viruses and pathogen in the etiology of infectious diseases in children with immunosuppression of different nature to provide an adequate etiotropic therapy and prophylaxis of these infections.

Materials and Methods.

We examined 30 children with immunosuppression due to congenital HIV infection and 30 children receiving immunosuppressive drug therapy after liver transplantation.

Results.

Identified a high prevalence of markers of GWI and pneumocystosis in children with immunosuppression of various etiologies. Acute Pneumocystis infection was detected in 36.7% of cases, among children receiving long-term immunosuppressive therapy, while in HIV-infected children with acute pneumocystosis detected only in 10% of cases. Reactivation of persistent infection was more frequently detected in children receiving immunosuppressive therapy after liver transplantation. At the same time, statistically significant differences are obtained only in respect of WABI (in children after liver transplantation — 26,7%, in children with HIV — 6,7%) and HHV-6 — 16,7% and 0%, respectively. Markers moved Pneumocystis infection were identified in the group of children receiving immunosuppressive drug therapy, 16,7%, while in children with HIV infection markers migrated pneumocystosis not diagnosed.

Conclusions.

the study showed a high prevalence of markers of GWI and pneumocystosis in children with immunosuppression of different etiology with a prevalence rate of infection by these pathogens among children receiving long-term immunosuppressive therapy. Identified a large number of active cases (both acute and reactivation) and recent infection (convalescence) caused by the herpes viruses and Pneumocystis in children with pharmacologic immunosuppression, which necessitates the appointment of etiotropic drugs: antiviral and Biseptol, in the first hours after transplantation of the liver.

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