Telavancin — New Antimicrobial Active Against Multiresistant Gram-Positive Pathogens. Clinical and Microbiological Features in Questions and Answers | CMAC

Telavancin — New Antimicrobial Active Against Multiresistant Gram-Positive Pathogens. Clinical and Microbiological Features in Questions and Answers

Clinical Microbiology and Antimicrobial Chemotherapy. 2015; 17(2):127-145

​ Dekhnich A.V., Zubareva N.A., Kozlov R.S., Popov D.A., Romanov A.V., Rudnov V.A.
telavancin glycopeptides MRSA skin and soft tissue infections nosocomial pneumonia bloodstream infections
Section
Antimicrobials
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2015; 17(2):127-145

Abstract

Telavancin is a first marketed representative of semisinthetic lipoglycopeptides — new generation of glycopeptide antimicrobials. Telavancin is registered for the treatment of nosocomial pneumonia and skin and soft tissue infections caused by Gram(+) microorganisms, including multiresistant strains. Another perspective area of telavancin use — bloodstream infections, such as bacteremia and endocarditis. Telavancin is in vitro active against broad range of Gram(+) aerobic and anaerobic bacteria, including strains resistant to other antimicrobials: MRSA, MRSE, VISA, daptomycin non-susceptible strains of S. aureus, penicillin-resistant S. pneumoniae, ampicillin-resistant enterococci and enterococci with VanB phenotype of resistance to vancomycin. Talavancin is rapidly bactericidal due to its dual mechanism of action; it is active against intracellular bacterial cells and biofilmforming cells. Article reviews data of current in vitro and in vivo studies of telavancin, as well as clinical trials results.

Andrey V. Dekhnich

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Zubareva N.A.

Perm State Medical University, Perm, Russia

Roman S. Kozlov

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Popov D.A.

Scientific Centre of Cardiac Surgery named after A.N. Bakulev, Moscow, Russia

Andrey V. Romanov

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Vladimir A. Rudnov

Ural State Medical University, Perm, Russia

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