bloodstream infections

Objective. To study epidemiology and impact of colonization by multidrug-resistant Gram-negative bacteria (MDRGNB) on bloodstream infections (BSI) during allogeneic hematopoietic stem cell transplantation (allo-HSCT). Materials and Methods. The retrospective study included 288 patients received the first allo-HSCT between 2018 and 2019. The median age was 32 (18–66) years, male – 53% (n = 152). The majority of patients had acute leukemia – 62% (n = 178) and received transplant from matched unrelated – 42% (n = 120) or haploidentical donor – 26% (n = 75).

Staphylococcal infections are widespread among outpatients and hospitalized patients. Despite the apparent diversity of the “menu” of anti-staphylococcal drugs, treatment results in several patients are not good as expected. This is due to the …

Telavancin is a first marketed representative of semisinthetic lipoglycopeptides — new generation of glycopeptide antimicrobials. Telavancin is registered for the treatment of nosocomial pneumonia and skin and soft tissue infections caused by Gram(+) …

Objective. To assess the use of MALDI-TOF MS and the experimental «Septi-Panel» assay (quantitative PCR method) in the screening of pathogens in blood culture. Materials and Methods. A total of 50 positive blood cultures (BactAlert) obtained from adult patients and newborns with suspected sepsis were included in the study. Pathogen detection were performed by direct mass-spectrometry, quantitative PCR using «Septi-Panel» assay, and culture. Results. Of 50 positive blood cultures tested, 76% and 92% of microorganisms were identified to species by direct mass-spectrometry and quantitative PCR, respectively.

Catheter-associated bloodstream infections take a third place among nosocomial infections, and are the most common cause of bacteremia. These infections account for 10% of all infections in hospitalized patients, 20% of nosocomial infections and up …