Etiology of Infective Endocarditis in Russia | CMAC

Etiology of Infective Endocarditis in Russia

Clinical Microbiology and Antimicrobial Chemotherapy. 2015; 17(1):4-10

​ Danilov A.I., Alekseeva I.V., Asner T.V., Vlasova E.E., Danilova E.M., Dekhnich A.V., Drozdovich E.L., Eger Yu.V., Elokhina E.V., Kalyagin A.N., Kozlov R.S., Krechikova O.I., Litvinov A.V., Milyagin V.A., Mladov V.V., Ortenberg E.A., Palyutin Sh.H., Portnyagina U.S., Rog A.A., Trushin I.V., Fedorova O.B., Fominykh S.G., Shames D.V., Shpuntov M.G., Yakupova S.P.
infective endocarditis etiology antimicrobial resistance
Section
Diseases and Pathogens
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2015; 17(1):4-10

Objective.

To investigate etiology of infective endocarditis in Russian Federation.

Materials and Methods.

Multicenter prospective (September 2011 to December 2013) and retrospective (January 2006 – September 2011) studies to investigate etiology of infective endocarditis (IE) were performed at medical institutions in 10 Russian cities. Patients with definite or possible diagnosis of IE who have at least 1 blood culture collected were enrolled in the study.

Results.

A total of 401 patients with IE were included in the analysis: 161 (40.1%) prospective cases and 240 (59.9%) retrospective cases. Probable pathogens were isolated from 145 patients (36.2%). Gram-positive bacteria were the most prevalent pathogens – 88.3% (n=125), specifically Staphylococcus aureus (46.2% of all isolates). Methicillin resistance was found in 28.4% (19⁄67) of S. aureus isolates and 38.1% (8⁄21) of coagulasenegative staphylococci. Most enterococci isolates were resistant to gentamicin (61.9%).

Conclusions.

Gram-positive bacteria are the most common pathogens in patients with IE in Russian Federation, with S. aureus as a predominant one. The high beta-lactam and aminoglycoside resistance rates in staphylococci and enterococci, respectively, would make it difficult to select appropriate therapy for IE.

Andrey I. Danilov

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Alekseeva I.V.

Republic Hospital #2 – Center for Emergency Medical Care, Yakutsk, Russia

Asner T.V.

Irkutsk State Medical University, Irkutsk, Russia

Vlasova E.E.

City Clinical Hospital #15 named after O.M. Filatov, Moscow, Russia

Danilova E.M.

Children Outpatient Clinic #4, Smolensk, Russia

Andrey V. Dekhnich

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Drozdovich E.L.

Northern State Medical University, Arkhangelsk, Russia

Eger Yu.V.

Clinical Emergency Care Hospital, Smolensk, Russia

Elokhina E.V.

Omsk Regional Clinical Hospital, Omsk, Russia

Kalyagin A.N.

Irkutsk State Medical University, Irkutsk, Russia

Roman S. Kozlov

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Olga I. Krechikova

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Alexander V. Litvinov

Smolensk State Medical University, Smolensk, Russia

Milyagin V.A.

Smolensk State Medical University, Smolensk, Russia

Mladov V.V.

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Eduard A. Ortenberg

Tyumen State Medical Academy, Tyumen, Russia

Palyutin Sh.H.

Yaroslavl State Medical Academy, Yaroslavl, Russia

Portnyagina U.S.

Republic Hospital #2 – Center for Emergency Medical Care, Yakutsk, Russia

Rog A.A.

City Clinical Hospital #15 named after O.M. Filatov, Moscow, Russia

Ivan V. Trushin

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Fedorova O.B.

Hospital named after N.N. Semashko, Moscow, Russia

Stella G. Fominykh

Omsk State Medical Academy, Omsk, Russia

Shames D.V.

Kazan State Medical University, Kazan, Russia

Shpuntov M.G.

Smolensk State Medical University, Smolensk, Russia

Yakupova S.P.

Kazan State Medical University, Kazan, Russia

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