Antimicrobial Resistance of Gram-negative Bacteria Isolated from Biopsy Samples in Patients with Ulcerative Colitis

Clinical Microbiology and Antimicrobial Chemotherapy. 2010; 12(4):342-346

Journal article


To investigate spectrum and antimicrobial susceptibility of colonic microorganisms isolated from biopsy samples in patients with ulcerative colitis.

Materials and Methods.

A total of 34 patients with ulcerative colitis (19 to 75 years of age) treated in proctology unit (Surgery Clinic of Samara State Medical University) during the 2009–2010 were examined in this study.


A total of 70 gram-negative isolates were obtained, of which Enterobacteriaceae were the most predominant pathogens. Non-fermenting gram-negative bacteria were significantly rare species. ESBL production was found in 40.9% of E. coli and 43.8% of Klebsiella spp. The most in vitro active antimicrobials against tested strains were carbapenems.


Etiology and optimal approach to the treatment of ulcerative colitis need further investigation; however, where gram-negative bacteria play a role, antimicrobial regimens should be chosen based on local resistance data and corrected according to culture and susceptibility testing results.

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