Antimicrobial Resistance of H. pylori and Susceptibility Determination Methods

Clinical Microbiology and Antimicrobial Chemotherapy. 2010; 12(1):57-66

Journal article


At present, primary, secondary, and multiple resistance of H. pylori to antimicrobial agents tends to increase, which significantly affects efficacy of eradication therapy. There were found significant differences in antimicrobial resistance of H. pylori between Russian regions, which indicate a need for multicenter epidemiological studies. A common use of molecular methods in clinical laboratory practice would allow detection of resistant strains and their prevalence changes, assessment of H. pylori eradication therapy outcomes and, possibly, identification of patient populations with specific genotypes conferring resistance to standard regimens for eradication. This paper provides a review of currently available data on antimicrobial resistance of H. pylori and its mechanisms as well as susceptibility determination methods for this pathogen.

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