Резистентность H. pylori к антибактериальным препаратам и методы её определения

Клиническая Микробиология и Антимикробная Химиотерапия. 2010; 12(1):57-66

​ Исаева Г.Ш.
антибиотикорезистентность эффлюкс определение чувствительности
Раздел
Антибиотикорезистентность
Тип
Журнальная статья
Публикация
Клиническая Микробиология и Антимикробная Химиотерапия. 2010; 12(1):57-66

Аннотация

Во всем мире, в том числе в нашей стране, отмечена тенденция к распространению первичной, вторичной и множественной устойчивости H. pylori к антибактериальным препаратам, что значительно снижает эффективность противохеликобактерной терапии. Выявлены существенные различия в уровнях антибиотикорезистентности H. pylori в различных регионах России, что указывает на назревшую необходимость проведения многоцентровых исследований. Широкое внедрение молекулярно-генетических методов исследований в практических лабораториях позволит выявлять циркуляцию резистентных штаммов и динамику их распространения, оценивать результаты эрадикационной терапии и, возможно, в будущем определять группы больных с определёнными генотипами, определяющими резистентность к стандартным схемам противохеликобактерной терапии. В статье представлен обзор современных представлений о распространении антибиотико­резистентности Helicobacter pylori, её механизмах и методах определения чувствительности этого микроорганизма к антибактериальным препаратам.

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