Antimicrobial Resistance of S. aureus Isolated from Infants with Skin and Soft Tissue Infections | CMAC

Antimicrobial Resistance of S. aureus Isolated from Infants with Skin and Soft Tissue Infections

Clinical Microbiology and Antimicrobial Chemotherapy. 2009; 11(4):356-361

​ Reshedko G.K., Avdeeva T.G., Stunzhas O.S., Ivanchik N.V.
infants skin and soft tissue infections S. aureus susceptibility antimicrobial therapy
Section
Personal Experience
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2009; 11(4):356-361

Abstract

The most common pathogens of skin and soft tissue infections (SSTI) as well as pharmacodynamics parameters of different antimicrobials against S. aureus are considered in this paper. A total of 80 clinical S. aureus isolates obtained from children (0 to 3 years of age) with SSTI in Smolensk outpatient clinics during 2006–2008 were tested. Susceptibility testing was performed by agar dilution method using the following antimicrobial agents: fusidic acid, gentamicin, mupirocin, ciprofloxacin, levofloxacin, erythromycin, clindamycin, lincomycin, tetracycline, chloramphenicol, co-trimoxazole, vancomycin, linezolid, rifampicin, oxacillin, netilmicin. The most in vitro active antimicrobials (susceptibility 100%) were linezolid, vancomycin, mupirocin, fusidic acid, netilmicin, and co-trimoxazole. High resistance rates among tested S. aureus isolates were observed for ciprofloxacin (32%), tetracycline (31%), chloramphenicol (26.5%), clindamycin (21%), erythromycin (26%), gentamicin (16%), and levofloxacin (16%). Incidence of methicillin-resistant S. aureus (MRSA) was 16%. Based on the susceptibility testing results, appropriate antimicrobials for empiric therapy of infants with SSTI in outpatient settings were proposed.

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