Clinical Microbiology and Antimicrobial Chemotherapy. 2009; 11(2):161-169
Escherichia coli is one of the main nosocomial pathogens. Recently antibiotic resistance of the pathogen has grown considerably. During our study resistance of 388 nosocomial E. coli isolated in intensive care units (ICUs) different regions of Russia in 2002–2004 and 124 strains isolated in 2006–2008 was studied. Amikacin, amoxicillin/ clavulanic acid, ampicillin, cefepime, cefoperazone, cefoperazone/sulbactam, cefotaxime, cefotaxime/clavulanic acid, ceftazidime, ceftriaxone, ciprofloxacin, co-trimoxazole, doripenem, ertapenem, fosfomycin, gentamicin, imipenem, levofloxacin, meropenem, moxifloxacin, netilmicin, piperacillin, piperacillin/tazobactam, ticarcillin/clavulanic acid were tested. Carbapenems (imipenem, meropenem, ertapenem, doripenem) showed the maximal activity with 0–0.5% resistant strains. Production of extended spectrum β-lactamases was seen in 49.7% strains in 2002–2004 and 76.6% strains in 2006–2008.