Use of fosfomycin trometamol in the Treatment of Lower Urinary Tract Infections

Abstract

In the treatment of uncomplicated urinary tract infec-tions the following groups of antimicrobial are of clinical use: fluoroquinolones, trimethoprim/sulfamethoxazole, nitrofurantoin, fosfomycin (one dose). In uncomplicated acute cystitis the short 3 days courses of antimicrobials are preferred. Short courses have the number of advan-tages such as: the lower selective pressure on antimi-crobial resistance, lower rates of adverse reactions, high compliance and lower cost of treatment. But only few groups of antimicrobials could be used in short courses: fluoroquinolones, trimethoprim/sulfamethoxazole, nitro-furantoin, and fosfomycin with the last one available for one dose therapy. During last decade fosfomycin is a drug of particular interest for the treatment of UTI due to emerging and spreading of resistance in E. coli to fluo-roquinolones and trimethoprim/sulfamethoxazole. At the same time resistance to fosfomycin is rare with 0–1.5% of uropathogenic E. coli strains non-susceptible in different regions of Russia.