Clinical Microbiology and Antimicrobial Chemotherapy. 2003; 5(1):4-18
Genital herpes (GH) is widely distributed sexually transmitted disease that is caused by herpes simplex virus type 1 nd 2. This article presents the questions of epidemiology and pathogenesis of this infection. Clinical features and major criteria for diagnosis of GH are described in detail. Special attention is paid to the questions of specific antiviral therapy of GH, such as treatment of primary GH, episodic antiviral therapy, prophylactic use of antiviral agents. Perspectives of therapy and prophylaxis of GH, including specific antivirals as well as vaccines and immunomodulatory agents are also discussed.