Clinical Microbiology and Antimicrobial Chemotherapy. 2002; 4(3):200-232
At the present time Clostridium difficile is the main causative pathogen of nosocomial diarrhea, that linked to the use of antimicrobials. But at the same time there is an unjustified little attantion paid to this problem in Russia. In the present literature review the following topics are described in details: the epidemiology of C. difficile infection; the microorganism – macroorganism interaction and the role of different factors of pathogenesity; the clinical manifestation of different C. difficile-associated pathologies; the comparative characteristic of different methods for the diagnosis of C. difficile infection; recent approaches to the therapy of this infection.