Clinical Microbiology and Antimicrobial Chemotherapy. 2001; 3(2):126-132
Translated and reprinted with permission from «Emerging Infectious Diseases» 2000; 6:552-6. Resistance of Streptococcus pneumoniae to antimicrobial drug is increasing. To investigate the relationship between antimicrobial use and susceptibility of S.pneumoniae isolates at 24 U.S. medical centers, we obtained data on outpatient antimicrobial-drug use for the regions surrounding 23 of these centers. We found an association between decreased penicillin susceptibility and use of b-lactam antimicrobial drugs.