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Personal Experience

Analysis of Antiviral and Antibacterial Therapy in Patients with Influenza A/H1N1 and Pneumonia

Analyzing the cases of treatment of pneumonia with influenza A/H1N1 in the background, it was noted that the outpatient antiviral therapy was provided mainly by «Arbidol». Neuraminidase inhibitors (Oseltamivir and Zanamivir) were used very …

Questionable Efficacy of Generics in the Treatment of Severe Community-Acquired Pneumonia

The retrospective analysis of treatment of patients with severe community-acquired pneumonia has been performed. It has demonstrated that the results of therapy with generic preparations of ceftriaxone and levofloxacin were inferior to original drug …

The Importance of the Adequate Empiric Antimicrobial Therapy in Nosocomial Infections Caused by Acinetobacter baumannii

Objective. To evaluate the influence of adequate empiric antimicrobial therapy for the outcome and the length of hospitalization in patients with nosocomial infections, caused by Acinetobacter baumannii. Materials and Methods. The subject of the research was 42 patients with nosocomial infections, caused by A. baumannii (middle age 53.3±5 year; 61.9% were males). The evaluation of the interrelation between patient’s outcome and adequacy of the empiric antimicrobial therapy was performed using odds ratio method and χ2-criterion to prove the results.

Wound Infections: a Role of Microbiological Monitoring for the Hospital Antimicrobial Policy

During the last 7 years the leading pathogens in the etiology of skin and soft tissue infections in the hospital were Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli and Pseudomonas аeruginosа. Statistical prognosis does not suggest …

Pharmacoepidemiologic, Clinical, and Microbiological Study on Antimicrobial Therapy of Inflammatory Diseases of Maxillofacial Area

This paper presents the results of a study to evaluate pharmacological therapy in inflammatory diseases of maxillofacial area in outpatient and hospital settings. The study included a review of medical records for outpatients (n = 600) and …

Knowledge Level on Etiology and Therapy of Keratitis among Ophthalmologists in Smolensk, Kaluga and Orel Regions

This paper presents the results of the study to evaluate knowledge level of ophthalmologists on risk factors, etiology, diagnosis, and treatment of keratitis. A total of 65 ophthalmologists in 3 regions (Smolensk, Kaluga, and Orel) completed …

Detection of Hungarian Pandemic MRSA Clone in Russia

Since 1961, pandemic methicillin-resistant S. aureus (MRSA) clones causing severe nosocomial infections have been distributed worldwide. The Hungarian clone having ST239 genotype and Staphylococcal cassette chromosome mec (SCCmec) type III is one of …

Clinical Significance of Bacteremia in Patients with Sepsis

An analysis of all bacteremia cases associated with systemic inflammatory response syndrome among patients hospitalized to City Clinical Hospital named after S.P. Botkin (Moscow) over the 2000–2007 was performed. A total of 303 positive blood culture …

Detection of Atopobium vaginae in Women of Childbearing Age with Bacterial Vaginosis

Bacterial vaginosis (BV) is a syndrome characterized by replacement of a normal (resident) vaginal flora with an association of anaerobic microorganisms. The most recently described novel microorganism, Atopobium vaginae, may be involved in …

Antagonistic Activity of Probiotic Bacteria

Objective. Objective: To investigate antagonistic activity of multicomponent probiotic products resulting from interactions of microorganisms; to develop bacterial selection criteria for multi-component biological products. Materials and Methods. Culture fluid of the paired probiotic strain associations: Bifidobacterium longum with Enterococcus faecium («Bifiform» product), Escherichia coli M-17 («Colibacterin» product) and Lactobacillus plantarum 8РА-3 («Lactobacterin» product) were tested for bactericidal activity against Staphylococcus aureus. Also, culture fluid of the each strain was treated with metabolites and peptidoglycan of the associative species and then tested for bactericidal activity against Staphylococcus aureus.