Clinical Microbiology and Antimicrobial Chemotherapy. 2013; 15(4):309-314
The study of the prevalence of ESBL CTX-M type of nosocomial strains of Enterobacteriaceae was perfomed. CTX-M enzymes have been identified in all ESBLproducing strains of Enterobacteriaceae. Identified β-lactamases belonged to the four genetic groups: CTXM1, CTX-M2, CTX-M8 and CTX-M9. The highest frequency of CTX-M type ESBL of various related groups was found among K. pneumoniae. Results estimation of sensitivity of CTX-M type ESBL producing strains to various antimicrobial were revealed a low frequency of sensitive strains to cephalosporins III–IV generation drugs and fluoroquinolones (ciprofloxacin). Slightly higher sensitivity was found in regard to aminoglycosides (amikacin, netilmicin).