Personal Experience

Objective. To explore potential of anti-Pseudomonas vaccine for the prophylaxis and treatment of infections caused by Pseudomonas aeruginosa in patients with severe burn trauma. Materials and Methods. This was a pilot, singlecenter randomized, parallel group study which enrolled patients with burns involving 10 to 60% of the body surface area. A total of 24 patients have received a course of «Pseudovac» vaccine (vaccination group), and 24 patients were included in the control arm (non-vaccination group).

The problem of genotypic variety of Acinetobacter baumannii isolated from patients with healthcare associated infections (HCAIs) are discussed. Carbapenemresistant strains, which are predominant in the study region, were shown to belong to the …

Objective. Aim. To evaluate current susceptibility patterns of the potential ocular bacterial pathogens to netilmicin in comparison with other antimicrobials in Russia. Materials and Methods. Overall in the study were included 200 S. aureus strains (100 — MRSA), 50 — coagulase-negative staphylococci, 50 — P. aeruginosa, 50 — Acinetobacter spp., and 50 — Enterobacteriaceae strains, isolated from outpatients and inpatients located in 17 cities of different regions of Russia during 2010–2014.

Relationship between presepsin values and shortterm status of patients with infections, as well as a correlation of presepsin levels and other markers of systemic inflammatory response were analyzed in this prospective observational study. The study …

The results of the immune response intensity and duration in 890 hospital staff after vaccination against hepatitis B are presented. High frequency of HBsAg (1,7%), anti-HBs (21,1%), anti-HВe (16,9%) among not vaccinated against hepatitis B medical …

Objective. Aim. To evaluate the antimicrobial susceptibility of group A streptococci (GAS) of different emm-genotypes, isolated from patients with invasive and non-invasive skin and soft tissue infections. Materials and Methods. Overall 91 strains of GAS isolated during 2008–2011 from patients with invasive and non-invasive skin and soft tissue infections hospitalized in one Moscow’s hospital were included in the study. Identification was done by latex agglutination, genotyping — by CDC protocol.

This study was performed to investigate activity of chlorhexidine-based antiseptic preparation «Dezin» against the following pathogens causing nosocomial respiratory tract infections (RTI) and urinary tract infections (UTI): Klebsiella pneumoniae …

Using the results from the previous experiments on N-glycans of hepatitis C virus (HCV) glycoprotein E1 in the process of structure viral proteins assembling in the model system (insect cells Sf9 and baculovirus expression system), simulation of …

Objective. To develop and characterize experimental model of chlamydial arthritis in rats. Materials and Methods. Wistar male rats received an intra-articular injection of 0.15–0.20 ml of purified elementary bodies of Chlamydophila (Chlamydia) trachomatis L2/Bu-434 or Chlamydophila (Chlamydia) muridarum Nigg. Animals were divided into two groups: young rats (body weight: 350-380 g) and adult rats (body weight: 450–500 g). Results. No changes in the affected joints were observed in rats infected with C.

Objective. Objectives. In vitro study of biofilm forming capacity of S. aureus and S. epidermidis strains, most common etiological agents of PJI following orthopedic surgeries, depending on source of strain, species of etiological agent and methicillin susceptibility. Materials and Methods. 241 S. aureus and 153 S. epidermidis strains, isolated from the tissue biopsies, the join aspirates and removed orthopedic prosthesis in 2012 year from 321 patients with PJI were investigated.