Antimicrobials

Objective. To assess a susceptibility to antibiotic combinations in nosocomial carbapenemase-producing Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii isolates using a modified method of multiple combination bactericidal testing (MCBT). Materials and Methods. A total of 178 isolates (63 K. pneumoniae isolates, 31 P. aeruginosa isolates, 84 A. baumannii isolates) obtained in the 2013-2017 from hospitalized patients in 28 public health organizations in 4 Belarus regions were included in the study.

An analysis of current trends in the prevalence of nosocomial infections, their etiology and antibiotic resistance in pathogens was performed. Social and economic consequences of antimicrobial resistance as well as a medical community’s response were …

This review characterizes daptomycin as a highly effective lipopeptide antibiotic being active against Gram-positive microorganisms, including multidrug resistant strains. The data reflecting the up-to-date daptomycin-based approaches to …

The rapid spread of multidrug-resistant Gram-negative bacteria in hospital settings all over the world makes a demand for the new options to overcome antimicrobial resistance. Ceftazidime-avibactam is the first approved antibiotic that contains a new …

This study assessed vancomycin concentrations in standard dosing regimens in a routine clinical practice and determined factors affecting their variability. Patients with normal renal function more often experienced low trough serum vancomycin …

Currently, from 15 to 50% of the population in the developed countries has obesity. Overall, patients with obesity have a higher risk of infection; they are more likely to develop infectious complications after surgical interventions and have a …

n May 2016, US FDA advised to restrict fluoroquinolones use in patients with acute sinusitis, acute exacerbations of chronic bronchitis, and uncomplicated urinary tract infections. The reason for this decision was the new safety data obtained during …

Wound healing and wound infection is not enough standardized in practice of surgeon. Existing recommendations on local antimicrobial agents do not contain references to specific products and do not explain their key features. The role of antiseptics …

Tedizolid is a novel oxazolidinone that has been recently approved for the treatment of acute bacterial skin and skin structure infections (ABSSSIs) caused by Gram-positive pathogens, including MRSA. The mechanism of action of tedizolid is similar to …

One of the most common problems in neonatal hospitals is the choice of metrics of drugs usage in neonatology, especially use of antibiotics. This study represents our experience in quantifying antibiotic use in a Level-III neonatal intensive care …