Clinical Microbiology and Antimicrobial Chemotherapy. 2019; 21(2):92-99
Over the last decades, probiotic strains for topical administration (including oral cavity) have appeared in clinical practice. Streptococcus salivarius K12 is a promising probiotic for prevention and treatment of the upper respiratory tract and ENT infections, and for maintenance of healthy oral microbiota. The review represents mechanisms of action of oral probiotics and the results of clinical studies of the S. salivarius K12 strain in various medical conditions.