Antimicrobials

This study was performed to evaluate a potential of ribavirin for inhibiting Batai virus replication in vitro. Ribavirin manufactured by ICN Switzerland AG (Switzerland) was used for the study. The drug and specific immune ascitic fluid were added to …

This paper reviews general issues of the use of antimicrobial agents in pregnant women. Currently available data on safety of macrolides during pregnancy and lactation are considered with the focus on several indications for their therapeutic and …

Introduction. In the conditions of dramatic rising of antibacterial resistance of gram-negative nosocomial pathogens, carbapenems plays a leading part as empiric antibacterial therapy, particularly in severe infections. Carbapenems on Russian pharmaceutical market presented by the original products and the number of generics from the India and other countries. Objective. The aim of the study was to compare the quality of original meropenem product and one of the generics. Materials and Methods.

This paper reviews some issues concerning comparison of pharmaceutical quality and bioequivalence between original drug products and their generics. A need for periodic routine monitoring of the currently marketed drug products and more stringent …

Piperacillin/tazobactam, penicillin/beta-lactamase inhibitor combination, has a broad antimicrobial spectrum, including most gram-positive cocci and gram-negativeaerobic and anaerobic bacteria (including beta-lactamase producing microorganisms). …

Spiramycin, natural 16-membered macrolide antibiotic, was discovered in 1954. This antimicrobial agent is at least non-inferior to and has some advantages over the currently available macrolides in spectrum of activity, pharmacological properties, …

The present article describes comparative pharmacokinetic study of different generic oral forms of amoxicillin — soluble tablets «Flemoxin Solutab», manufactured by «Astellas Pharma Europe B.V.», Netherlands, and powder for suspension «Amosin», …

According to the mutant selection window (MSW) hypothesis resistant mutants are selected at antibiotic concentrations above the MIC but below the mutant prevention concentration (MPC). There are contradictory reports on the relationships between MIC- …

Telavancin (TLV) is an investigational lipoglycopeptide with multiple mechanism of action. It exhibits rapid bactericidal activity against gram-positive bacteria, including methicillin-susceptible and -resistant, glycopeptide-intermediate and …

The carbapenems are class of beta-lactam antibiotics with exceptionally wide spectrum of activity, beneficial pharmacokinetic parameters and low toxicity as well. Such agents as imipenem and meropenem have already been succesfully used for a long …