Clinical Microbiology and Antimicrobial Chemotherapy. 2011; 13(1):67-84
There are many antibiotics from various chemical classes available in drug armamentarium for the treatment of community-acquired infections at out-patient basis. In such cases safety and tolerability of administered treatment is of no less importance than its efficacy. Recent data suggest that adverse drug reactions associated with the use of antibiotics represent about 20% of all drug-related emergency department visits. This article reviews the most significant adverse drug reactions of antibiotics used for out-patient treatment. Special attention is devoted to those reactions which are commonly underappreciated by general practitioners. Safety information presented in this review may prove to be useful for choosing of the safest antibiotic for an individual patient.