safety

The title of this review “War and peace” is not accidental and the analogies with a well-known literary masterpiece have absolutely justified ground. As in the case of Lev Tolstoy’s novel this title has a profound philosophical meaning, although at …

Adverse drug reactions affecting gastrointestinal tract, quite often with the development of antibioticassociated diarrhea, are the most common undesirable effects of antibiotic therapy in outpatient practice. This review provides modern approaches …

Objective. To evaluate the efficacy and safety of a step-down strategy from intravenous to oral nemonoxacin versus a step-down strategy from intravenous to oral levofloxacin in the treatment of patients with community-acquired pneumonia. Materials and Methods. This was a phase III randomized, controlled, double-blind, double-dummy, parallel groups (2 groups), multicenter trial to evaluate the efficacy and safety of intravenous and oral nemonoxacin at a daily dose of 500 mg versus levofloxacin (Tavanic®) at a daily dose of 500 mg in the treatment of adult patients with community-acquired pneumonia.

Macrolide antimicrobials are widely used for the treatment of variety of community-acquired bacterial infections. This paper is aimed to review the data on the safety issues of erythromycin. The main attention is paid to the studies on erythromycin …

n May 2016, US FDA advised to restrict fluoroquinolones use in patients with acute sinusitis, acute exacerbations of chronic bronchitis, and uncomplicated urinary tract infections. The reason for this decision was the new safety data obtained during …

This article describes the factors contributing reduced efficacy of antimicrobial agents in elderly patients, as well as the factors and mechanisms compromising safety of this drug class. Specific aspects of the administration of different …

This paper considers safety issues associated with medical therapy of sexually transmitted diseases (STDs). Data supporting safety of azithromycin as part of treatment regimens for infections due to chlamydia and mycoplasma are provided. Possible …

According to international post-marketing trials, levofloxacin now belongs to the antimicrobial agents being in a great demand in clinical practice. One of the main indications for its use is community-acquired pneumonia (CAP). This review article is …

There are many antibiotics from various chemical classes available in drug armamentarium for the treatment of community-acquired infections at out-patient basis. In such cases safety and tolerability of administered treatment is of no less importance …

This paper reviews general issues of the use of antimicrobial agents in pregnant women. Currently available data on safety of macrolides during pregnancy and lactation are considered with the focus on several indications for their therapeutic and …