Clinical Microbiology and Antimicrobial Chemotherapy. 2011; 13(4):322-334
Infections caused by resistant microorganisms are of particular concern for both healthcare providers and public health authorities due to associated significant social and economic losses. Improper use of antimicrobial agents, selective pressure, and «collateral damage» phenomenon are all the most important causes of dramatic deterioration of microbial ecology globally. It’s well known that implementation of certain antimicrobial stewardship programs can have significant effect on emergence and spread of antimicrobial resistance. Appropriate choice of empiric antimicrobial therapy is one of the key parameters of its prudent use; hence, proposed approach to patient stratification by the risk of multidrug resistant pathogens could be useful in practice.